Chaperoning RNA Polymerase II through repressive chromatin

被引：2
|
作者：
Faralli, Herve [1 ]
Dilworth, F. Jeffrey [1 ,2 ]
机构：
[1] Ottawa Hosp Res Inst, Regenerat Med Program, Sprott Ctr Stem Cell Res, Ottawa, ON, Canada
[2] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada
来源：
EMBO JOURNAL | 2013年 / 32卷 / 08期
基金：
加拿大健康研究院;
关键词：
GENE-EXPRESSION; ELONGATION;
D O I：
10.1038/emboj.2013.64
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The histone chaperone Spt6 is known to facilitate transcriptional elongation while preventing spurious initiation of transcription within the coding region of genes. A recent publication in The EMBO Journal (Wang et al, 2013) identifies an additional mechanism by which Spt6 promotes gene expression by demonstrating that it tethers the histone demethylase UTX/KDM6A to the elongating RNA Polymerase II, thereby enabling the removal of repressive H3K27me3 marks within developmentally important muscle genes.
引用
收藏
页码：1067 / 1068
页数：2
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