Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients carrying TTN mutations

被引：0

作者：

Zhang, Tina Tianbo ^{[1
,2
]}

Zhao, Shane Rui ^{[1
,2
]}

Alamana, Christina ^{[1
,2
]}

Shen, Mengcheng ^{[1
,2
]}

Parikh, Victoria ^{[1
,2
]}

Wheeler, Matthew T. ^{[1
,2
]}

Wu, Joseph C. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Stanford Cardiovasc Inst, Sch Med, Stanford, CA USA

[2] Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA USA

[3] 265 Campus Dr, G1120B, Stanford, CA 94305 USA

来源：

STEM CELL RESEARCH | 2022年 / 65卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.scr.2022.102941

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Dilated cardiomyopathy (DCM) is a common heart disease that can lead to heart failure and sudden cardiac death. Mutations in the TTN gene are the most frequent cause of DCM. Here, we generated two human induced pluripotent stem cell (iPSC) lines from the peripheral blood mononuclear cells (PBMCs) of two DCM patients carrying c.94816C>T and c.104188A>G mutations in TTN, respectively. The two lines exhibited a normal morphology, full expression of pluripotency markers, a normal karyotype and the ability of trilineage differentiation. The two lines can serve as useful tools for drug screening and mechanism studies on DCM.

引用

页数：5

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