Mathematical and computational method for electrical analysis of biological tissues

被引：4
|
作者：
Ramos, Airton [1 ]
Weinert, Rodolfo Lauro [1 ]
机构：
[1] Univ Estado Santa Catarina, Dept Elect Engn, Appl Electromagnet Res Grp, 200 Campus Univ Prof Avelino Marcante, BR-89219710 Joinville, SC, Brazil
来源：
JOURNAL OF COMPUTATIONAL ELECTRONICS | 2018年 / 17卷 / 01期
关键词：
Equivalent circuit method; Biological tissues; Electroporation; Electrical analysis; IMPEDANCE METHOD; ELECTROPORATION; ELECTROCHEMOTHERAPY;
D O I：
10.1007/s10825-017-1070-z
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
This paper presents the mathematical and computational methods for the implementation of the equivalent circuit method including a thermal and electroporation calculation for the analysis of the electric response of biological tissues excited by high-voltage pulses applied through metallic electrodes. A mathematical method for evaluating the dynamic behavior of cell membrane conductance is proposed based on the electroporation asymptotic model of Neu and Krassowska. Ex vivo electroporation experiments on rat liver samples were performed, and experimental results for electrical current and surface temperature of the sample were used to adjust several parameters of the electroporation model. The adjustments provided good agreement between computational and experimental results.
引用
收藏
页码：382 / 391
页数：10
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