A Novel Stimuli-Responsive Magnetite Nanocomposite as De Novo Drug Delivery System

被引：13
|
作者：
Mozafari, Zahra [1 ]
Massoumi, Bakhshali [1 ]
Jaymand, Mehdi [2 ]
机构：
[1] Payame Noor Univ, Dept Chem, POB 19395-3697, Tehran, Iran
[2] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
来源：
POLYMER-PLASTICS TECHNOLOGY AND MATERIALS | 2019年 / 58卷 / 04期
关键词：
ATRP; cancer chemotherapy; magnetite nanosystem; smart drug delivery; stimuli responsive; COATED GOLD NANORODS; BLOCK-COPOLYMERS; THERMAL-BEHAVIOR; NANOPARTICLES; HYDROGELS; POLYMERIZATION; NANOCAPSULES; SHELL;
D O I：
10.1080/03602559.2018.1471718
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A novel stimuli-responsive magnetite nanocomposite as de novo drug delivery system for cancer chemotherapy is developed successfully through the incorporation of magnetite nanoparticles into PEG-b-(PNIPAAm-b-PAA)(2) copolymer. The chemical structures of samples were characterized using FTIR and H-1 NMR spectroscopies. Furthermore, thermal property, morphology, size, and magnetic properties of the nanocomposite were investigated. The DOX loading and encapsulation efficiencies as well as stimuli-responsive drug release ability of the nanosystem were studied. As results, at pH 5.3 and temperature of 41 degrees C the nanocomposite exhibited higher drug release values, which qualified it for cancer chemotherapy according to especial features of cancerous tissue. [GRAPHICS] .
引用
收藏
页码：405 / 418
页数：14
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