Application of capillary electrophoresis to the determination of various benzylpenicillin salts

被引：25
|
作者：
Pajchel, G [1 ]
Michalska, K [1 ]
Tyski, S [1 ]
机构：
[1] Natl Inst Publ Hlth, Dept Antibiot & Microbiol, PL-00725 Warsaw, Poland
来源：
JOURNAL OF CHROMATOGRAPHY A | 2004年 / 1032卷 / 1-2期
关键词：
pharmaceutical analysis; benzylpenicillin; procaine; benzathine; clemizole; antibiotics;
D O I：
10.1016/j.chroma.2003.11.014
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The application of capillary electrophoresis for separation of benzylpenicillin, procaine, benzathine and clemizole was investigated. Phosphate-borate buffer supplemented with sodium dodecyl sulphate 14.4 g/l and electrophoresis voltage 18 kV seem to provide optimal conditions for micellar electrokinetic chromatographic assay of penicillin salts. This method is selective and precise. The results obtained from CE method recovery assay (above 98% for all but procaine-97% substances) and from determination of benzylpenicillin by CE compared with HPLC results, confirmed good accuracy. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：265 / 272
页数：8
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