High copy number of mitochondrial DNA predicts poor prognosis in patients with advanced stage colon cancer

被引：31
|
作者：
Wang, Yun [1 ]
He, Shuixiang [1 ]
Zhu, Xingmei [2 ]
Qiao, Wei [3 ]
Zhang, Juan [1 ]
机构：
[1] Xi An Jiao Tong Univ, Hosp 1, Dept Gastroenterol & Hepatol, 277 Yanta West Rd, Xian 710061, Peoples R China
[2] Shaanxi Univ Chinese Med, Coll Pharm, Xianyang, Peoples R China
[3] Ordnance Ind 521 Hosp, Dept Gastroenterol & Hepatol, Xian, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 2016年 / 31卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Clinical outcome; Colon cancer; Copy number; Mitochondrial DNA; qRT-PCR; COLORECTAL-CANCER; WORSE PROGNOSIS; MTDNA; INSTABILITY; VIETNAMESE;
D O I：
10.5301/jbm.5000211
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Introduction: The aim of this investigation was to determine whether alterations in mitochondrial DNA ( mtDNA) copy number in colon cancer were associated with clinicopathological parameters and postsurgical outcome. Methods: By quantitative real-time PCR assay, the mtDNA copy number was detected in a cohort of colon cancer and matched adjacent colon tissues (n = 162). Results: The majority of patients had higher mtDNA content in colon cancer tissues than matched adjacent colon tissues. Moreover, high mtDNA content in tumor tissues was associated with larger tumor size, higher serum CEA level, advanced TNM stage, vascular emboli, and liver metastases. Further survival curve analysis showed that high mtDNA content was related to the worst survival in patients with colon cancer at advanced TNM stage. Conclusions: High mtDNA content is a potential effective factor of poor prognosis in patients with advanced stage colon cancer.
引用
收藏
页码：E382 / E388
页数：7
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