Physical and functional interactions between hematopoietic cell-specific ETS transcription factors and homeodomain proteins

被引：7
|
作者：
Yamada, Toshiyuki [1 ]
Shimizu, Takeshi [1 ]
Sakurai, Takuya [2 ]
Nanashima, Naoki [1 ]
Kihara-Negishi, Fumiko [3 ]
Suzuki, Mitsuhiro [4 ]
Fan, Yang [1 ]
Akita, Miki [1 ]
Oikawa, Tsuneyuki [5 ]
Tsuchida, Shigeki [1 ]
机构：
[1] Hirosaki Univ, Grad Sch Med, Dept Biochem & Genome Biol, Hirosaki, Aomori 0368562, Japan
[2] Kyorin Univ, Sch Med, Dept Mol Predict Med & Sport Sci, Tokyo, Japan
[3] Teikyo Univ, Fac Pharmaceut Sci, Kanagawa, Japan
[4] Univ Occupat & Environm Hlth, Sch Med, Dept Biochem & Mol Pathophysiol, Kitakyushu, Fukuoka 807, Japan
[5] Hlth Sci Univ Hokkaido, Dept Commun Disorders, Sapporo, Hokkaido, Japan
来源：
LEUKEMIA RESEARCH | 2009年 / 33卷 / 03期
关键词：
ETS family of transcription factors; Homeodomain proteins; Functional interaction; Physical interaction; Hematopoiesis; Leukemogenesis; HOMEOBOX GENES; DOMAIN;
D O I：
10.1016/j.leukres.2008.07.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To examine the possibility that ETS family transcription factors, PU.1, SPI-B, ELF-1, ERG-3, ETS-1 and TEL, and homeodomain proteins, HOXA10, HOXC13, MEIS1 and PBX1B, function cooperatively, we investigated their interactions. In luciferase assays, HOXA10 and HOXC 13 augmented the activity of PU.1 and SPI-B while diminishing that of ELF-1 and ERG-3. MEIS1 diminished the activity of ETS-1. No clear effects were observed for other combinations. Immunoprecipitation assays showed protein-protein interactions among the combinations exhibiting functional interactions. A mutation of HOXC13, which abolished binding to ELF-1, also abolished the diminishing effect on ELF-1. The results suggest functional interaction through physical interactions. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：483 / 489
页数：7
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