Physical and functional interactions between hematopoietic cell-specific ETS transcription factors and homeodomain proteins

被引：7

作者：

Yamada, Toshiyuki ^{[1
]}

Shimizu, Takeshi ^{[1
]}

Sakurai, Takuya ^{[2
]}

Nanashima, Naoki ^{[1
]}

Kihara-Negishi, Fumiko ^{[3
]}

Suzuki, Mitsuhiro ^{[4
]}

Fan, Yang ^{[1
]}

Akita, Miki ^{[1
]}

Oikawa, Tsuneyuki ^{[5
]}

Tsuchida, Shigeki ^{[1
]}

机构：

[1] Hirosaki Univ, Grad Sch Med, Dept Biochem & Genome Biol, Hirosaki, Aomori 0368562, Japan

[2] Kyorin Univ, Sch Med, Dept Mol Predict Med & Sport Sci, Tokyo, Japan

[3] Teikyo Univ, Fac Pharmaceut Sci, Kanagawa, Japan

[4] Univ Occupat & Environm Hlth, Sch Med, Dept Biochem & Mol Pathophysiol, Kitakyushu, Fukuoka 807, Japan

[5] Hlth Sci Univ Hokkaido, Dept Commun Disorders, Sapporo, Hokkaido, Japan

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 03期

关键词：

ETS family of transcription factors; Homeodomain proteins; Functional interaction; Physical interaction; Hematopoiesis; Leukemogenesis; HOMEOBOX GENES; DOMAIN;

D O I：

10.1016/j.leukres.2008.07.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To examine the possibility that ETS family transcription factors, PU.1, SPI-B, ELF-1, ERG-3, ETS-1 and TEL, and homeodomain proteins, HOXA10, HOXC13, MEIS1 and PBX1B, function cooperatively, we investigated their interactions. In luciferase assays, HOXA10 and HOXC 13 augmented the activity of PU.1 and SPI-B while diminishing that of ELF-1 and ERG-3. MEIS1 diminished the activity of ETS-1. No clear effects were observed for other combinations. Immunoprecipitation assays showed protein-protein interactions among the combinations exhibiting functional interactions. A mutation of HOXC13, which abolished binding to ELF-1, also abolished the diminishing effect on ELF-1. The results suggest functional interaction through physical interactions. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：483 / 489

页数：7

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