Inhibiting Human Breast Cancer Cell Growth In Vitro of a Novel Heterocycles Compound

被引：0
|
作者：
Kong, Ying [1 ]
Yang, Chong [1 ]
Su, Yanyan [1 ]
Ying, Jiake [1 ]
Ye, Yu [1 ]
机构：
[1] Hangzhou Red Cross Hosp, Dept Gen Surg, Hangzhou, Zhejiang, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2017年 / 36卷 / 12期
关键词：
anti-breast cancer; heterocycles; single crystal; SORAFENIB; HPLC;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The new heterocycles compound N-(4-bromo-3-(trifluoromethyl) phenyl)-N'-(4-(2-(N-methylcarbamoyl)- 4-pyridyloxy)phenyl)urea (3), designed using 4-chloro-N-methyl-2-pyridinecarboxamide (1) as start material, was successfully obtained via multiple synthesis route and finally characterized by IR, H-1 NMR, HRMS, and single crystal X-ray crystallography. In addition, the anti-breast cancer effects of compound 3 was studied on three human breast cancer cell lines including SKBr-3, ZR-75-30 and MCF7. The results showed that compared with the positive reference drug carboplatin, compound 3 displayed efficient anti-breast cancer activity.
引用
收藏
页码：2369 / 2373
页数：5
相关论文
共 50 条
  • [41] A novel natural inhibitor of extracellular signal-regulated kinases and human breast cancer cell growth
    Izevbigie, EB
    Bryant, JL
    Walker, A
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2004, 229 (02) : 163 - 169
  • [42] Human serum albumin-mediated apoptin delivery suppresses breast cancer cell growth in vitro and in vivo
    Wu, Fang
    Liu, Yizhi
    Li, Jian
    Hou, Lei
    Lei, Fuxi
    Huang, Shangke
    Feng, Lu
    Zhao, Xinhan
    ONCOLOGY LETTERS, 2017, 13 (02) : 579 - 586
  • [43] Effects of vinorelbine on epidermal growth factor-receptor binding of human breast cancer cell lines in vitro
    Depenbrock, H
    Shirvani, A
    Rastetter, J
    Hanauske, AR
    INVESTIGATIONAL NEW DRUGS, 1995, 13 (03) : 187 - 193
  • [44] Physiological melatonin inhibition of human breast cancer cell growth in vitro: Evidence for a glutathione-mediated pathway
    Blask, DE
    Wilson, ST
    Zalatan, F
    CANCER RESEARCH, 1997, 57 (10) : 1909 - 1914
  • [45] The effect of genistein upon estrogen receptor negative human breast cancer cell growth in vitro and in vivo.
    Santell, RC
    Kieu, N
    Helferich, WG
    FASEB JOURNAL, 1998, 12 (05): : A655 - A655
  • [46] Involvement of plasminogen activator inhibitor PAI-1 in in vitro growth of human breast cancer cell lines
    Prifti, S
    Fersis, N
    Sillem, M
    Szekelyi, M
    Runnebaum, B
    Bastert, G
    EUROPEAN JOURNAL OF CANCER, 1998, 34 : S17 - S18
  • [47] Novel 4-hydroxycoumarin derivatives: Inhibiting growth of human lung cancer cells
    Chen, Lan-Tao
    Zhu, Kai-Bin
    Qu, Chang-Fa
    MAIN GROUP CHEMISTRY, 2018, 17 (04) : 301 - 307
  • [48] Salvianolic acid B, a natural compound, showing anti-cancer activity by inhibiting breast cancer cell proliferation and inducing cell apoptosis
    Sha, Wei
    Zhou, Yanfei
    Ji, Hongguang
    Shan, Liang
    Pang, Xiaowu
    Califano, Joseph
    Gu, Xinbin
    CANCER RESEARCH, 2009, 69
  • [49] In vitro growth inhibition of human cancer cells by novel honokiol analogs
    Lin, Jyh Ming
    Gowda, A. S. Prakasha
    Sharma, Arun K.
    Amin, Shantu
    BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (10) : 3202 - 3211
  • [50] Inhibiting telomerase to deter cancer cell growth
    不详
    CHEMICAL & ENGINEERING NEWS, 1999, 77 (40) : 28 - 28
12345