Inhibiting Human Breast Cancer Cell Growth In Vitro of a Novel Heterocycles Compound

被引：0
|
作者：
Kong, Ying [1 ]
Yang, Chong [1 ]
Su, Yanyan [1 ]
Ying, Jiake [1 ]
Ye, Yu [1 ]
机构：
[1] Hangzhou Red Cross Hosp, Dept Gen Surg, Hangzhou, Zhejiang, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2017年 / 36卷 / 12期
关键词：
anti-breast cancer; heterocycles; single crystal; SORAFENIB; HPLC;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The new heterocycles compound N-(4-bromo-3-(trifluoromethyl) phenyl)-N'-(4-(2-(N-methylcarbamoyl)- 4-pyridyloxy)phenyl)urea (3), designed using 4-chloro-N-methyl-2-pyridinecarboxamide (1) as start material, was successfully obtained via multiple synthesis route and finally characterized by IR, H-1 NMR, HRMS, and single crystal X-ray crystallography. In addition, the anti-breast cancer effects of compound 3 was studied on three human breast cancer cell lines including SKBr-3, ZR-75-30 and MCF7. The results showed that compared with the positive reference drug carboplatin, compound 3 displayed efficient anti-breast cancer activity.
引用
收藏
页码：2369 / 2373
页数：5
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