Genetic diversity and antifungal susceptibility of Candida albicans isolated from Iranian patients

被引：7
|
作者：
Sharifynia, Somayeh [1 ,2 ]
Rezaie, Sasan [2 ]
Mohamadnia, Abdolreza [3 ,4 ]
Mortezaee, Vida [5 ,6 ]
Hadian, Atefe [2 ]
Seyedmousavi, Seyedmojtaba [5 ,6 ,7 ,8 ,9 ,10 ]
机构：
[1] Shahid Beheshti Univ Med Sci, NRITLD, Clin TB & Epidemiol Res Ctr, Tehran, Iran
[2] Univ Tehran Med Sci, Sch Publ Hlth, Div Mol Biol, Dept Med Mycol & Parasitol, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, NRITLD, Virol Res Ctr, Tehran, Iran
[4] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Biotechnol, Tehran, Iran
[5] Mazandaran Univ Med Sci, Sch Med, Invas Fungi Res Ctr, Sari, Iran
[6] Mazandaran Univ Med Sci, Sch Med, Dept Med Mycol & Parasitol, Sari, Iran
[7] Ctr Excellence Infect Biol & Antimicrobial Pharma, Dept Microbiol & Immunol, Tehran, Iran
[8] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, Nijmegen, Netherlands
[9] RadboudUMC CWZ, Ctr Expertise Mycol, Nijmegen, Netherlands
[10] NIAID, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
来源：
MEDICAL MYCOLOGY | 2019年 / 57卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Candida albicans; microsatellite genotyping; antifungal susceptibility; Iran; BLOOD-STREAM INFECTIONS; POLYMORPHIC MICROSATELLITE; IDENTIFICATION; EPIDEMIOLOGY; SURVEILLANCE; FUNGEMIA; CANCER; PCR;
D O I：
10.1093/mmy/myy016
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
A total of 105 independent Candida albicans strains isolated from patients in Iran were investigated. According to CLSI documents M27-A3 and M27-S4, the 24 h geometric mean MICs of caspofungin, itraconazole, and fluconazole were 0.27, 3.19, and 11.91g/ml, respectively. Microsatellites analysis of CEF3, CAIII, LOC4 Loci identified 93 different allelic genotypes clustered apart into six different clades. Antifungal susceptibility was not linked with the source of isolation and the corresponding genotype of C. albicans strains.
引用
收藏
页码：127 / 131
页数：5
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