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- [27] A Double-Edged Sword?HEALTH SERVICES INSIGHTS, 2023, 16Azeez, Mohammad AnasSiddiqui, Zohaib HasanSohail, Shahab Saquib
Signaling via MYD88 in the pancreatic tumor microenvironment A double-edged sword
被引：14
|作者：
Zambirinis, Constantinos P.
[1
]
Miller, George
[1
,2
]
机构：
[1] NYU, Dept Surg, S Arthur Localio Lab, Sch Med, New York, NY 10016 USA
[2] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA
来源：
关键词：
cancer-associated inflammation;
dendritic cells;
innate immunity;
MYD88;
pancreatic cancer;
pattern-recognition receptors;
Toll-like receptors;
tumor microenvironment;
NEGATIVE REGULATION;
D O I：
10.4161/onci.22567
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have recently shown that Toll-like receptor (TLR) signaling exacerbates pancreatic fibro-inflammation and promotes carcinogenesis in mice. Paradoxically, inhibition of the TLR-MYD88 signaling pathway is pro-tumorigenic owing to the dendritic cell-mediated T(H)2-polarization of CD4(+) T cells. TLR signaling appears to be central in pancreatic cancer-associated inflammation.
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页数：3
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