Effects of discontinuation of chronic medication in primary care: a systematic review of deprescribing trials

Background Polypharmacy is becoming more prevalent and evaluation of appropriateness of medication use is increasingly important. The primary care physician often conducts the deprescribing process; however, thew are several barriers to implementing this. Aim To examine the feasibility and safety of discontinuation of medication, with a focus on studies that have been conducted in the community, that is, primary care for general practice) and nursing homes. Design and setting This systematic review included randomised controlled trials published in 2005-2017, which studied withdrawal of long-term drugs prescribed in primary care settings and compared continuing medication with discontinuing. Method PubMed and EMBASE searches were conducted and the extracted data included the number of patients who successfully stopped medication and the number of patients who experienced relapse of symptoms or restarted medication. Results A total of 27 studies reported in 26 papers were included in this review. The number of participants in the studies varied from 20 to 2471 and the mean age of participants ranged from 50.3 years to 89.2 years. The proportion of patients who successfully stopped their medication varied from 20% to 100%, and the range of reported relapse varied from 1.9% to 80%. Conclusion Only a few studies have examined the success rate and safety of discontinuing medication in primary Care, and these studies are very heterogeneous. Most studios show that deprescribing and cessation of long-term use seem safe; however, there is a risk of relapse of symptoms. More research is needed to advise physicians in making evidence-based decisions about deprescribing in primary care settings.