The Ethical and Scientific Shortcomings of Current Monotherapy Epilepsy Trials in Newly Diagnosed Patients

被引：13
|
作者：
Karlawish, Jason H. T.
French, Jacqueline
机构：
[1] Univ Penn, Alzheimers Dis Ctr, Philadelphia, PA 19104 USA
[2] Univ Penn, Ctr Bioeth, Div Geriatr, Dept Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA
来源：
EPILEPSY & BEHAVIOR | 2001年 / 2卷 / 03期
关键词：
epilepsy; clinical trials; research ethics; placebo controls;
D O I：
10.1006/ebeh.2001.0197
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
[No abstract available]
引用
收藏
页码：193 / 200
页数：8
相关论文
共 50 条
  • [41] Effectiveness and tolerability of perampanel monotherapy in children with newly diagnosed focal epilepsy
    Zhao, Fen
    Ren, Ying
    Geng, Guifu
    Zhang, Tong
    Hu, Wandong
    Zhang, Huan
    Jin, Ruifeng
    Shi, Jianguo
    Gao, Zaifen
    Zhang, Hongwei
    Liu, Yong
    FRONTIERS IN NEUROLOGY, 2023, 14
  • [42] Cognitive and Psychosocial Effects of Oxcarbazepine Monotherapy in Newly Diagnosed Partial Epilepsy
    Kim, Daeyoung
    Seo, Ji-Hye
    Joo, Eun Yeon
    Lee, Hyang Woon
    Shin, Won Chul
    Hong, Seung Bong
    CLINICAL NEUROPHARMACOLOGY, 2014, 37 (04) : 100 - 107
  • [43] PROGNOSIS OF NEWLY-DIAGNOSED EPILEPSY AND EFFECTS OF INITIAL VIGABATRIN MONOTHERAPY COMPARED WITH CARBAMAZEPINE MONOTHERAPY
    KALVIAINEN, R
    AIKIA, M
    MERVAALA, E
    SAUKKONEN, AM
    RIEKKINEN, PJ
    NEUROLOGY, 1994, 44 (04) : A204 - A204
  • [44] Effects of lamotrigine monotherapy in patients with newly diagnosed juvenile myoclonic epilepsy: An open-label study
    Schimschock, JR
    Hammer, AE
    Kustra, RP
    Messenheimer, JA
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 2005, 66 (03): : 230 - 237
  • [45] Effects of levetiracetam monotherapy on sperm parameters and sex hormones: Data from newly diagnosed patients with epilepsy
    Ceylan, Mustafa
    Yalcin, Ahmet
    Bayraktutan, Omer Faruk
    Karabulut, Ibrahim
    Sonkaya, Ali Riza
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2016, 41 : 70 - 74
  • [46] VIGABATRIN VS CARBAMAZEPINE MONOTHERAPY IN PATIENTS WITH NEWLY-DIAGNOSED EPILEPSY - A RANDOMIZED, CONTROLLED-STUDY
    KALVIAINEN, R
    AIKIA, M
    SAUKKONEN, AM
    MERVAALA, E
    RIEKKINEN, PJ
    ARCHIVES OF NEUROLOGY, 1995, 52 (10) : 989 - 996
  • [47] A randomised open multicentre comparative trial of lamotrigine and carbamazepine as monotherapy in patients with newly diagnosed or recurrent epilepsy
    Reunanen, M
    Dam, M
    Yuen, AWC
    EPILEPSY RESEARCH, 1996, 23 (02) : 149 - 155
  • [48] Alzemon: a prospective follow-up study of eslicarbazepine acetate monotherapy in patients with newly diagnosed epilepsy
    Hernandez-Rubio, Lidia
    Asensio-Asensio, Montserrat
    Tortosa-Conesa, Diego
    Alfaro-Saez, Aranzazu
    Garcia-Escriva, Alexandre
    Diaz-Roman, Monica
    Montoya, Javier
    Angeles Mendez-Miralles, M.
    Bertol-Alegre, Vicente
    Dolores Castro-Vilanova, M.
    Luisa Galiano, M.
    Empar Blanco-Canto, M.
    Lopez-Gonzalez, Fatima
    REVISTA DE NEUROLOGIA, 2021, 72 (08) : 263 - 268
  • [49] VIGABATRIN MONOTHERAPY IN NEWLY-DIAGNOSED PARTIAL EPILEPSY - AN OPEN MULTICENTER STUDY
    DEFEO, MR
    MECARELLI, O
    MARCIANI, MG
    STRIANO, S
    ORTENZI, A
    ALOISI, P
    DALESSANDRO, P
    ONOFRI, M
    EPILEPSIA, 1995, 36 : S105 - S105
  • [50] THE RISK FACTOR OF SKIN RASH ASSOCIATED WITH LAMOTRIGINE MONOTHERAPY IN NEWLY DIAGNOSED EPILEPSY
    Park, S-P
    Seo, J-G
    EPILEPSIA, 2013, 54 : 112 - 112
12345