THE ROLE OF INTESTINAL TIGHT JUNCTIONS IN PATHOGENESIS OF NECROTIZING ENTEROCOLITIS

被引：0
|
作者：
Borys, Franciszek [1 ]
Sibrecht, Greta [1 ]
Naskrecka, Dobrochna [1 ]
Wroblewska-Seniuk, Katarzyna [1 ]
Mazela, Jan [1 ]
机构：
[1] Dept Newborns Infect Dis, Poznan, Poland
来源：
POSTEPY BIOLOGII KOMORKI | 2018年 / 45卷 / 04期
关键词：
tight junctions; necrotizing enterocolitis; breast milk; probiotics; preterms; HUMAN-MILK; BARRIER DYSFUNCTION; RANDOMIZED-TRIAL; PRETERM FORMULA; GROWTH-FACTOR; BREAST-MILK; INFANTS; ERYTHROPOIETIN; GLUTAMINE; LACTOFERRIN;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Tight junctions are multiprotein junctional complexes fastening intestinal epithelial cells together. Their function is to regulate paracellular permeability and to maintain integrity of intestinal epithelial barrier. Disruption of this barrier is believed to be involved in necrotizing enterocolitis development in preterm infants. In this review article we would like to present recent studies involving the role of tight junctions in the pathogenesis of necrotizing enterocolitis and also analyse impact of breastmilk components and probiotics on this process.
引用
收藏
页码：269 / 282
页数：14
相关论文
共 50 条
  • [21] A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair
    Leaphart, Cynthia L.
    Cavallo, Jaime
    Gribar, Steven C.
    Cetin, Selma
    Li, Jun
    Branca, Maria F.
    Dubowski, Theresa D.
    Sodhi, Chhinder P.
    Hackam, David J.
    JOURNAL OF IMMUNOLOGY, 2007, 179 (07): : 4808 - 4820
  • [22] The Protective Role of Intestinal Alkaline Phosphatase in Necrotizing Enterocolitis
    Whitehouse, Jill S.
    Riggle, Kevin M.
    Purpi, David P.
    Mayer, Alan N.
    Pritchard, Kirkwood A., Jr.
    Oldham, Keith T.
    Gourlay, David M.
    JOURNAL OF SURGICAL RESEARCH, 2010, 163 (01) : 79 - 85
  • [23] The role of intestinal alkaline phosphatase in the development of necrotizing enterocolitis
    Martins, Raquel Dos Santos
    Kooi, Elisabeth M. W.
    Poelstra, Klaas
    Hulscher, Jan B. F.
    EARLY HUMAN DEVELOPMENT, 2023, 183
  • [24] Role of Intestinal Microflora on Necrotizing Enterocolitis in Preterm Infants
    Wu, Lijuan
    Lin, Hung-Chih
    JOURNAL OF PEDIATRIC BIOCHEMISTRY, 2015, 5 (02) : 55 - 59
  • [25] Editorial: Intestinal Microbiota in the Pathogenesis and Management of Necrotizing Enterocolitis in Preterm Infants
    Guo, Chunbao
    Shi, Yuan
    FRONTIERS IN PEDIATRICS, 2022, 10
  • [26] PATHOGENESIS OF NEONATAL NECROTIZING ENTEROCOLITIS
    LAWRENCE, GW
    BATES, J
    LANCET, 1983, 1 (8323): : 540 - 540
  • [27] Pathogenesis of neonatal necrotizing enterocolitis
    Joanna C. Lim
    Jamie M. Golden
    Henri R. Ford
    Pediatric Surgery International, 2015, 31 : 509 - 518
  • [28] Necrotizing enterocolitis: pathogenesis and treatment
    Pierro, A
    BRITISH JOURNAL OF HOSPITAL MEDICINE, 1997, 58 (04): : 126 - 128
  • [29] PATHOGENESIS OF NEONATAL NECROTIZING ENTEROCOLITIS
    GRAY, ES
    LLOYD, DJ
    HORNE, CHW
    LANCET, 1982, 1 (8269): : 451 - 451
  • [30] Necrotizing enterocolitis leads to disruption of tight junctions and increase in gut permeability in a mouse model
    Ravisankar, Srikanth
    Tatum, Rodney
    Garg, Parvesh M.
    Herco, Maja
    Shekhawat, Prem S.
    Chen, Yan-Hua
    BMC PEDIATRICS, 2018, 18
12345