From Anilines to Aziridines: A Two-Step Synthesis under Continuous-Flow Conditions

被引：11

作者：

Rossi, Sergio ^{[1
]}

Puglisi, Alessandra ^{[1
]}

Intrieri, Daniela ^{[1
]}

Gallo, Emma ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Chim, Via Golgi 19, I-20133 Milan, Italy

来源：

JOURNAL OF FLOW CHEMISTRY | 2016年 / 6卷 / 03期

关键词：

azides; aziridines; ruthenium catalyst; mesoreactors; flow chemistry; C-H AMINATION; ARYL AZIDES; ORGANIC AZIDES; DIAZO-COMPOUNDS; VISIBLE-LIGHT; CATALYSTS; CHEMISTRY; ORGANOCATALYSIS; GENERATION; ALKENES;

D O I：

10.1556/1846.2016.00027

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Sandmeyer reaction of anilines to generate aryl azides, followed by the Ru(porphyrin)CO-catalyzed addition to styrenes affording N-aryl aziridines was successfully performed for the first time in mesoreactors, under continuous-flow conditions. Mesofluidic technology allowed for a rapid screening of different parameters and a quick identification of the optimized reaction conditions for the two separate steps. The two optimized reactions were then combined in a single continuous process that allowed a safe and efficient synthesis of N-arylaziridines from convenient commercially available starting materials.

引用

页码：234 / 239

页数：6

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