From Anilines to Aziridines: A Two-Step Synthesis under Continuous-Flow Conditions

被引：11
|
作者：
Rossi, Sergio [1 ]
Puglisi, Alessandra [1 ]
Intrieri, Daniela [1 ]
Gallo, Emma [1 ]
机构：
[1] Univ Milan, Dipartimento Chim, Via Golgi 19, I-20133 Milan, Italy
来源：
JOURNAL OF FLOW CHEMISTRY | 2016年 / 6卷 / 03期
关键词：
azides; aziridines; ruthenium catalyst; mesoreactors; flow chemistry; C-H AMINATION; ARYL AZIDES; ORGANIC AZIDES; DIAZO-COMPOUNDS; VISIBLE-LIGHT; CATALYSTS; CHEMISTRY; ORGANOCATALYSIS; GENERATION; ALKENES;
D O I：
10.1556/1846.2016.00027
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The Sandmeyer reaction of anilines to generate aryl azides, followed by the Ru(porphyrin)CO-catalyzed addition to styrenes affording N-aryl aziridines was successfully performed for the first time in mesoreactors, under continuous-flow conditions. Mesofluidic technology allowed for a rapid screening of different parameters and a quick identification of the optimized reaction conditions for the two separate steps. The two optimized reactions were then combined in a single continuous process that allowed a safe and efficient synthesis of N-arylaziridines from convenient commercially available starting materials.
引用
收藏
页码：234 / 239
页数：6
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