Diffuse optical tomography guided adaptive reconstruction in fluorescence molecular tomography

被引:1
|
作者
Li, Mingze [1 ]
Liu, Fei [1 ]
Zhang, Bin [1 ]
Bai, Jing [1 ]
机构
[1] Tsinghua Univ, Dept Biomed Engn, Beijing 100084, Peoples R China
基金
北京市自然科学基金; 中国国家自然科学基金;
关键词
ELEMENT BASED TOMOGRAPHY; 3-DIMENSIONAL RECONSTRUCTION; MESHING ALGORITHMS; BOUNDARY; SHAPE;
D O I
10.1117/1.JEI.21.2.023014
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
The adaptive finite element method (AFEM) is an effective way to retain enough resolution in selected regions while improving computational efficiency for reconstruction in fluorescent molecular tomography (FMT). In addition, background optical properties acquired by diffuse optical tomography (DOT) will improve the quality of reconstructed images. In this work, a DOT-guided adaptive reconstruction method (DGARM) is proposed, in which DOT is introduced into an adaptive reconstruction framework of FMT. Besides being used as functional a priori information in the forward modeling, the reconstructed local absorption coefficients in DOT are also used to form internal structural a priori information, which is further used to identify regions of interest (ROIs) in the mesh refinement of the adaptive procedure. Because optical properties are recovered before the formulation of FMT, a linear relationship is established between the fluorescent field and boundary measurements. We implemented numerical simulations and physical experiments to evaluate the performance of the algorithm. Compared with the strategies of uniform meshing with DOT and AFEM without DOT, DGAM improves localization accuracy of the reconstruction of fluorescence inclusion. (C) 2012 SPIE and IS&T. [DOI: 10.1117/1.JEI.21.2.023014]
引用
收藏
页数:10
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