Chemical Diversity and Biological Activities of Meroterpenoids from Marine Derived-Fungi: A Comprehensive Update

被引：28
|
作者：
El-Demerdash, Amr [1 ,2 ]
Kumla, Decha [3 ,4 ]
Kijjoa, Anake [3 ,4 ]
机构：
[1] John Innes Ctr, Dept Metab Biol, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England
[2] Mansoura Univ, Fac Sci, Chem Dept, Mansoura 35516, Egypt
[3] Univ Porto, ICBAS Inst Ciencias Biomed Abel Salazar, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal
[4] Univ Porto, CIIMAR, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal
来源：
MARINE DRUGS | 2020年 / 18卷 / 06期
关键词：
meroterpenoids; marine-derived fungi; biological activities; antibacterial; cytotoxicity; anti-inflammatory; A-D; ISOCOUMARIN; DERIVATIVES; STRAIN; INHIBITORS; ACIDS;
D O I：
10.3390/md18060317
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Meroterpenoids are a class of hybrid natural products, partially derived from a mixed terpenoid pathway. They possess remarkable structural features and relevant biological and pharmacological activities. Marine-derived fungi are a rich source of meroterpenoids featuring structural diversity varying from simple to complex molecular architectures. A combination of a structural variability and their myriad of bioactivities makes meroterpenoids an interesting class of naturally occurring compounds for chemical and pharmacological investigation. In this review, a comprehensive literature survey covering the period of 2009-2019, with 86 references, is presented focusing on chemistry and biological activities of various classes of meroterpenoids isolated from fungi obtained from different marine hosts and environments.
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页数：32
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