BRCA1 transactivates the cyclin-dependent kinase inhibitor p27Kip1

被引：49
|
作者：
Williamson, EA
Dadmanesh, F
Koeffler, HP
机构：
[1] Univ Calif Los Angeles, Sch Med, Dept Med, Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
[2] Univ Calif Los Angeles, Sch Med, Dept Anat Pathol, Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
来源：
ONCOGENE | 2002年 / 21卷 / 20期
关键词：
BRCA1; p27(Kip1); transcriptional regulation;
D O I：
10.1038/sj.onc.1205461
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The p27(Kip1) is a member of the universal cyclin-dependent kinase inhibitor family. Previously, immunochemical analysis of a series of breast cancer cell lines demonstrated a correlation between the expression of P27(Kip1) and the breast cancer susceptibility gene BRCA1. BRCA1 has a number of activities including DNA repair, growth inhibition and as a transcription factor. Here we demonstrate that BRCA1 transactivates expression of p27(Kip1). This transactivation is dependent on the presence of a functional C-terminal transactivation domain. Promoter-deletion analysis identified the presence of a putative BRCA1-responsive element located at position -615 to -511 of the p27(Kip1) promoter. These results suggest that the transcriptional regulation of p27(Kip1) by BRCA1 may be a mechanism for BRCA1- induced growth inhibition.
引用
收藏
页码：3199 / 3206
页数：8
相关论文
共 50 条
  • [41] Prognostic impact of cyclin-dependent kinase inhibitor p27kip1 node-positive breast cancer
    Tsuchiya, A
    Zhang, GJ
    Kanno, M
    [J]. JOURNAL OF SURGICAL ONCOLOGY, 1999, 70 (04) : 230 - 234
  • [42] The cyclin-dependent kinase inhibitor p27Kip1 is involved in thyroid hormone-mediated neuronal differentiation
    Perez-Juste, G
    Aranda, A
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (08) : 5026 - 5031
  • [43] Overexpression of a stabilized mutant form of the cyclin-dependent kinase inhibitor p27Kip1 inhibits cell growth
    Hurteau, JA
    Brutkiewicz, SA
    Wang, Q
    Allison, BM
    Goebl, MG
    Harrington, MA
    [J]. GYNECOLOGIC ONCOLOGY, 2002, 86 (01) : 19 - 23
  • [44] Accelerated turnover of taste bud cells in mice deficient for the cyclin-dependent kinase inhibitor p27Kip1
    Harrison, Theresa A.
    Adams, Lorraine B. Smith
    Moore, Preston D.
    Perna, Marla K.
    Sword, Jarrod D.
    Defoe, Dennis M.
    [J]. BMC NEUROSCIENCE, 2011, 12
  • [45] Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation
    Gustavo Baldassarre
    Maria Vittoria Barone
    Barbara Belletti
    Claudia Sandomenico
    Paola Bruni
    Stefania Spiezia
    Angelo Boccia
    Maria Teresa Vento
    Annunciata Romano
    Stefano Pepe
    Alfredo Fusco
    Giuseppe Viglietto
    [J]. Oncogene, 1999, 18 : 6241 - 6251
  • [46] Cyclin-dependent kinase inhibitor p27Kip1 expression in transitional cell carcinoma of renal pelvis and ureter
    Masuda, M
    Takano, Y
    Iki, M
    Makiyama, K
    Ikeda, I
    Noguchi, S
    Hasegawa, Y
    Hosaka, M
    [J]. CANCER LETTERS, 2000, 150 (02) : 183 - 189
  • [47] Low expression of p27Kip1, a cyclin-dependent kinase inhibitor, is a marker of poor prognosis in synovial sarcoma
    Kawauchi, S
    Goto, Y
    Liu, XP
    Furuya, T
    Oga, A
    Oda, Y
    Tsuneyoshi, M
    Ihara, K
    Sasaki, K
    [J]. CANCER, 2001, 91 (05) : 1005 - 1012
  • [48] Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation
    Baldassarre, G
    Barone, MV
    Belletti, B
    Sandomenico, C
    Bruni, P
    Spiezia, S
    Boccia, A
    Vento, MT
    Romano, A
    Pepe, S
    Fusco, A
    Viglietto, G
    [J]. ONCOGENE, 1999, 18 (46) : 6241 - 6251
  • [49] Accelerated turnover of taste bud cells in mice deficient for the cyclin-dependent kinase inhibitor p27Kip1
    Theresa A Harrison
    Lorraine B Smith Adams
    Preston D Moore
    Marla K Perna
    Jarrod D Sword
    Dennis M Defoe
    [J]. BMC Neuroscience, 12
  • [50] Adenoviral expression of the cyclin-dependent kinase inhibitor p27Kip1:: a strategy for breast cancer gene therapy
    Rakkar, ANS
    Li, ZW
    Katayose, Y
    Kim, M
    Cowan, KH
    Seth, P
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (23) : 1836 - 1838
12345