BRCA1 transactivates the cyclin-dependent kinase inhibitor p27Kip1

被引：49
|
作者：
Williamson, EA
Dadmanesh, F
Koeffler, HP
机构：
[1] Univ Calif Los Angeles, Sch Med, Dept Med, Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
[2] Univ Calif Los Angeles, Sch Med, Dept Anat Pathol, Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
来源：
ONCOGENE | 2002年 / 21卷 / 20期
关键词：
BRCA1; p27(Kip1); transcriptional regulation;
D O I：
10.1038/sj.onc.1205461
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The p27(Kip1) is a member of the universal cyclin-dependent kinase inhibitor family. Previously, immunochemical analysis of a series of breast cancer cell lines demonstrated a correlation between the expression of P27(Kip1) and the breast cancer susceptibility gene BRCA1. BRCA1 has a number of activities including DNA repair, growth inhibition and as a transcription factor. Here we demonstrate that BRCA1 transactivates expression of p27(Kip1). This transactivation is dependent on the presence of a functional C-terminal transactivation domain. Promoter-deletion analysis identified the presence of a putative BRCA1-responsive element located at position -615 to -511 of the p27(Kip1) promoter. These results suggest that the transcriptional regulation of p27(Kip1) by BRCA1 may be a mechanism for BRCA1- induced growth inhibition.
引用
收藏
页码：3199 / 3206
页数：8
相关论文
共 50 条
  • [1] BRCA1 transactivates the cyclin-dependent kinase inhibitor p27Kip1
    Elizabeth A Williamson
    Farnaz Dadmanesh
    H Phillip Koeffler
    [J]. Oncogene, 2002, 21 : 3199 - 3206
  • [2] Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27Kip1
    Hiromura, K
    Pippin, JW
    Fero, ML
    Roberts, JM
    Shankland, SJ
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (05): : 597 - 604
  • [3] Expression of cyclin-dependent kinase inhibitor p27kip1 in malignant lymphomas
    Oh, YH
    Park, CK
    [J]. JOURNAL OF KOREAN MEDICAL SCIENCE, 2000, 15 (04) : 399 - 406
  • [4] Modulation of astrocyte proliferation by cyclin-dependent kinase inhibitor p27Kip1
    Koguchi, K
    Nakatsuji, Y
    Nakayama, K
    Sakoda, S
    [J]. GLIA, 2002, 37 (02) : 93 - 104
  • [5] Adenoviral expression of the cyclin-dependent kinase inhibitor p27kip1:: A strategy for cholangiocarcinoma
    Katayose, Y
    Suzuki, M
    Unno, M
    Takemura, S
    Fujiwara, K
    Yamamoto, K
    Yoshida, H
    Cowan, KH
    Seth, P
    Matsuno, S
    [J]. GASTROENTEROLOGY, 1999, 116 (04) : A434 - A434
  • [6] The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury
    Vuddhidej Ophascharoensuk
    Matthew L. Fero
    Jeremy Hughes
    James M. Roberts
    Stuart J. Shankland
    [J]. Nature Medicine, 1998, 4 : 575 - 580
  • [7] The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury
    Ophascharoensuk, V
    Fero, ML
    Hughes, J
    Roberts, JM
    Shankland, SJ
    [J]. NATURE MEDICINE, 1998, 4 (05) : 575 - 580
  • [8] Minimal requirements for the nuclear localization of p27Kip1, a cyclin-dependent kinase inhibitor
    Zeng, Y
    Hirano, K
    Hirano, M
    Nishimura, J
    Kanaide, H
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 274 (01) : 37 - 42
  • [9] Prognostic value of the cyclin-dependent kinase inhibitor p27Kip1 in gastric cancer
    Müller, W
    Grabsch, H
    Takeno, S
    Noguchi, T
    Hommel, G
    Gabbert, HE
    [J]. ANTICANCER RESEARCH, 2000, 20 (3A) : 1787 - 1792
  • [10] Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 in feline lymphoma
    Madewell, B
    Griffey, S
    Walls, J
    Gandour-Edwards, R
    [J]. VETERINARY PATHOLOGY, 2001, 38 (06) : 698 - 702
12345