The two-signal model of T-cell activation after 30 years

被引：54
|
作者：
Bernard, A [1 ]
Lamy, L
Alberti, I
机构：
[1] Hop Archet, Immunol Lab, F-06202 Nice, France
[2] INSERM Unite 343, Nice, France
来源：
TRANSPLANTATION | 2002年 / 73卷 / 01期
关键词：
D O I：
10.1097/00007890-200201151-00011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The two-signal model of T-cell activation is still valid after 30 years. The recent understanding of the first signal intricacy and its tight relationship with the second signal have thrown decisive light on T-cell activation processes and the complex molecular events that occur on the surface and within the T cell. Furthermore, the recognition of numerous accessory pathways that, in addition to the CD28 and CD40 pathways, operate to manage antigen-presenting cell T cell cooperation in view of lymphocyte activation, disclose the exquisite and numerous regulatory events that compose the second signal.
引用
收藏
页码：S31 / S35
页数：5
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