Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease

被引：21
|
作者：
Gregorio, Michele L. [1 ]
Pinhel, Marcela A. S. [1 ,2 ]
Sado, Caroline L. [3 ]
Longo, Gabriela S. [4 ]
Oliveira, Fabio N. [4 ]
Amorim, Gisele S. [5 ]
Nakazone, Marcelo A. [1 ]
Florim, Greiciane M. [5 ]
Mazeti, Camila M. [5 ]
Martins, Denise P. [5 ]
Tognola, Waldir A. [6 ]
Brandao, Antonio C. [6 ]
Pinheiro Junior, Sidney [7 ]
de Godoy, Moacir F. [4 ]
Souza, Doroteia R. S. [3 ]
机构：
[1] Sao Jose do Rio Preto Med Sch FAMERP, Dept Mol Biol, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil
[2] NPBIM, Ctr Res Biochem & Mol Biol, Sao Jose do Rio Preto Med Sch FAMERP, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil
[3] Fed Univ Sao Paulo UNIFESP, BR-04021001 Sao Paulo, Brazil
[4] Hosp Base, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil
[5] Sao Jose do Rio Preto Med Sch FAMERP, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil
[6] Sao Jose do Rio Preto Med Sch FAMERP, Dept Neurosci Mol Biol, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil
[7] Sao Jose do Rio Preto Med Sch FAMERP, Dept Mol Biol, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil
来源：
BIOMED RESEARCH INTERNATIONAL | 2013年 / 2013卷
基金：
巴西圣保罗研究基金会;
关键词：
ONSET ALZHEIMERS-DISEASE; E EPSILON-4 ALLELE; E POLYMORPHISM; E GENOTYPES; CHOLESTEROL LEVELS; SERUM-CHOLESTEROL; OXIDATIVE STRESS; APOE ALLELES; RISK; ASSOCIATION;
D O I：
10.1155/2013/641515
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility to neurodegeneration. APOE gene has been considered a risk factor for PD. This study aimed to evaluate the association of APOE polymorphism with PD and its influence on lipid profile. We studied 232 PD patients (PD) and 169 individuals without the disease. The studied polymorphism was analyzed by PCR/RFLP. The Fisher's exact test, chi-square, ANOVA, and t-test (P < 0.05) were applied. The APOE3/3 genotype was prevalent in PD patients and Controls (P = 0.713) followed by APOE3/4 (P = 0.772). Both groups showed recommended values for lipid profile, with increase in the values of total cholesterol and LDLc, as well as decreased values of triglycerides in PD patients compared with Controls (P < 0.05 for all of them). Increased levels of HDLc, in PD patients, were associated with the APOE3/3 versus APOE-/4 genotypes (P = 0.012). The APOE polymorphism does not distinguish PD patients from Controls, as opposed to the lipid profile alone or in association with APOE. Furthermore, a relationship between increase of HDLc levels and APOE3 in homozygous was found in PD patients only.
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页数：7
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