Lack of genetic associations of alpha-1-antichymotrypsin polymorphism with Alzheimer-type neuropathological changes or sporadic Alzheimer's disease

被引：7
|
作者：
Sodeyama, N
Yamada, M
Itoh, Y
Suematsu, N
Matsushita, M
Otomo, E
Mizusawa, H
机构：
[1] Tokyo Med & Dent Univ, Dept Neurol, Bunkyo Ku, Tokyo 1138519, Japan
[2] Yokufukai Geriatr Hosp, Dept Internal Med, Tokyo, Japan
[3] Yokufukai Geriatr Hosp, Dept Pathol, Tokyo, Japan
[4] Tokyo Inst Psychiat, Dept Neuropathol, Tokyo, Japan
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 1999年 / 10卷 / 03期
关键词：
Alzheimer's disease; alpha(1)-antichymotrypsin; apolipoprotein E; neuropathological change; risk factor; Japanese;
D O I：
10.1159/000017123
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
To elucidate the influence of the al-antichymotrypsin (ACT) polymorphism on Alzheimer-type neuropathological changes and the development of sporadic Alzheimer's disease (AD), we studied the relationship between the ACT polymorphism and the severity of Alzheimer-type neuropathological changes in the brains from AD patients and nondemented subjects. There was no association of the ACT polymorphism with Alzheimer-type neuropathological changes in AD or nondemented individuals. ACT polymorphism was not associated with the development of AD, These results remained nonsignificant when the ACT genotype groups were divided into subgroups according to the apolipoprotein E (ApoE) epsilon 4 status. Our study shows that the ACT polymorphism has no effect on Alzheimer-type neuropathological changes or the development of AD, either alone or in combination with ApoE epsilon 4.
引用
收藏
页码：221 / 225
页数：5
相关论文
共 50 条
  • [21] Apolipoprotein E and alpha(1)-antichymotrypsin polymorphism in Alzheimer's disease
    Nacmias, B
    Tedde, A
    Latorraca, S
    Forleo, P
    Piacentini, S
    Sorbi, S
    Amaducci, L
    [J]. ANNALS OF NEUROLOGY, 1996, 40 (03) : M54 - M54
  • [22] SERUM ALPHA-1-ANTICHYMOTRYPSIN CONCENTRATIONS IN ALZHEIMER TYPE AND VASCULAR DEMENTIA
    YOSHIDA, Y
    OHTANI, Y
    KAWAGUCHI, T
    MURASAKI, M
    MIURA, S
    [J]. NEUROBIOLOGY OF AGING, 1994, 15 : S93 - S94
  • [23] No interaction between the APOE and the alpha-1-antichymotrypsin genes on risk for Alzheimer's disease
    Fallin, D
    Reading, S
    Schinka, J
    Hoyne, J
    Scibelli, P
    Gold, M
    Crawford, F
    Mullan, M
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 1997, 74 (02): : 192 - 194
  • [24] No genetic effect of alpha(1)-antichymotrypsin in Alzheimer disease
    Haines, JL
    Pritchard, ML
    Saunders, AM
    Schildkraut, JM
    Growdon, JH
    Gaskell, PC
    Farrer, LA
    Auerbach, SA
    Gusella, JF
    Locke, PA
    Rosi, BL
    Yamaoka, L
    Small, GW
    Conneally, PM
    Roses, AD
    PericakVance, MA
    [J]. GENOMICS, 1996, 33 (01) : 53 - 56
  • [25] alpha 1-antichymotrypsin polymorphism in Japanese cases of Alzheimer's disease
    Yoshizawa, T
    YamakawaKobayashi, K
    Hamaguchi, H
    Shoji, S
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1997, 152 (02) : 136 - 139
  • [26] Apolipoprotein E and α-1-antichymotrypsin allele polymorphism in sporadic and familial Alzheimer's disease
    Licastro, F
    Pedrini, S
    Govoni, M
    Pession, A
    Ferri, C
    Annoni, G
    Casadei, V
    Veglia, F
    Bertolini, S
    Grimaldi, LME
    [J]. NEUROSCIENCE LETTERS, 1999, 270 (03) : 129 - 132
  • [27] Apolipoprotein E and alpha-1-antichymotrypsin genotypes do not predict time to psychosis in Alzheimer's disease
    Sweet, RA
    Kamboh, MI
    Wisniewski, SR
    Lopez, OL
    Klunk, WE
    Kaufer, DI
    DeKosky, ST
    [J]. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 2002, 15 (01) : 24 - 30
  • [28] Alpha-1-antichymotrypsin bi-allele polymorphism, apolipoprotein-E tri-allele polymorphism and genetic risk of Alzheimer's syndrome
    Thome, J
    Baumer, A
    Kornhuber, J
    Rosler, R
    Riederer, P
    [J]. JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION, 1995, 10 (2-3) : 207 - 212
  • [29] Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease
    Kamboh, M. Ilyas
    Minster, Ryan L.
    Kenney, Margaret
    Ozturk, Ayla
    Desai, Purnima P.
    Kammerer, Candace M.
    DeKosky, Steven T.
    [J]. NEUROBIOLOGY OF AGING, 2006, 27 (10) : 1435 - 1439
  • [30] Alzheimer-type neuropathological changes in morbidly obese elderly individuals
    Mrak, Robert Emil
    [J]. FASEB JOURNAL, 2007, 21 (05): : A73 - A73
12345