Lack of genetic associations of alpha-1-antichymotrypsin polymorphism with Alzheimer-type neuropathological changes or sporadic Alzheimer's disease

被引：7
|
作者：
Sodeyama, N
Yamada, M
Itoh, Y
Suematsu, N
Matsushita, M
Otomo, E
Mizusawa, H
机构：
[1] Tokyo Med & Dent Univ, Dept Neurol, Bunkyo Ku, Tokyo 1138519, Japan
[2] Yokufukai Geriatr Hosp, Dept Internal Med, Tokyo, Japan
[3] Yokufukai Geriatr Hosp, Dept Pathol, Tokyo, Japan
[4] Tokyo Inst Psychiat, Dept Neuropathol, Tokyo, Japan
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 1999年 / 10卷 / 03期
关键词：
Alzheimer's disease; alpha(1)-antichymotrypsin; apolipoprotein E; neuropathological change; risk factor; Japanese;
D O I：
10.1159/000017123
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
To elucidate the influence of the al-antichymotrypsin (ACT) polymorphism on Alzheimer-type neuropathological changes and the development of sporadic Alzheimer's disease (AD), we studied the relationship between the ACT polymorphism and the severity of Alzheimer-type neuropathological changes in the brains from AD patients and nondemented subjects. There was no association of the ACT polymorphism with Alzheimer-type neuropathological changes in AD or nondemented individuals. ACT polymorphism was not associated with the development of AD, These results remained nonsignificant when the ACT genotype groups were divided into subgroups according to the apolipoprotein E (ApoE) epsilon 4 status. Our study shows that the ACT polymorphism has no effect on Alzheimer-type neuropathological changes or the development of AD, either alone or in combination with ApoE epsilon 4.
引用
收藏
页码：221 / 225
页数：5
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