Horizontal gene transfer in the human gastrointestinal tract: potential spread of antibiotic resistance genes

被引：355
|
作者：
Huddleston, Jennifer R. [1 ]
机构：
[1] Abilene Christian Univ, Dept Biol, ACU Box 27868, Abilene, TX 79699 USA
来源：
INFECTION AND DRUG RESISTANCE | 2014年 / 7卷
关键词：
gut microbiome; conjugation; natural transformation; transduction; LONG-TERM PERSISTENCE; LACTIC-ACID BACTERIA; ESCHERICHIA-COLI; NATURAL TRANSFORMATION; SOS RESPONSE; AMPICILLIN RESISTANCE; PLASMID TRANSFER; LARGE-INTESTINE; ANIMAL ORIGIN; DNA TRANSPORT;
D O I：
10.2147/IDR.S48820
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Bacterial infections are becoming increasingly difficult to treat due to widespread antibiotic resistance among pathogens. This review aims to give an overview of the major horizontal transfer mechanisms and their evolution and then demonstrate the human lower gastrointestinal tract as an environment in which horizontal gene transfer of resistance determinants occurs. Finally, implications for antibiotic usage and the development of resistant infections and persistence of antibiotic resistance genes in populations as a result of horizontal gene transfer in the large intestine will be discussed.
引用
收藏
页码：167 / 176
页数：10
相关论文
共 50 条
  • [21] Organic contaminants influence the horizontal transfer of antibiotic resistance genes
    Hu, Xiaojie
    Qin, Chao
    Gao, Yanzheng
    CHINESE SCIENCE BULLETIN-CHINESE, 2022, 67 (35): : 4224 - 4235
  • [22] Comprehensive analysis of disinfectants on the horizontal transfer of antibiotic resistance genes
    Zhu, Shuyao
    Yang, Bingqing
    Jia, Yuqian
    Yu, Feiyu
    Wang, Zhiqiang
    Liu, Yuan
    JOURNAL OF HAZARDOUS MATERIALS, 2023, 453
  • [23] Microplastics exhibit accumulation and horizontal transfer of antibiotic resistance genes
    Feng, Yue
    Sun, Jia-Wen
    Shi, Wei-Wei
    Duan, Jian-Lu
    Sun, Xiao-Dong
    Feng, Li-Juan
    Wang, Qian
    Gan, Yu-Dong
    Yuan, Xian-Zheng
    JOURNAL OF ENVIRONMENTAL MANAGEMENT, 2023, 336
  • [24] Influence of hydrous oxides on the horizontal transfer of antibiotic resistance genes
    Li, Xiao-Jia
    Liu, Si
    Wang, Ting-Ting
    Qin, Chao
    Hu, Xiao-Jie
    Gao, Yan-Zheng
    Zhongguo Huanjing Kexue/China Environmental Science, 2024, 44 (03): : 1622 - 1629
  • [25] Metagenomic analysis of human, animal, and environmental samples identifies potential emerging pathogens, profiles antibiotic resistance genes, and reveals horizontal gene transfer dynamics
    Rajindra Napit
    Anupama Gurung
    Ajit Poudel
    Ashok Chaudhary
    Prajwol Manandhar
    Ajay Narayan Sharma
    Samita Raut
    Saman Man Pradhan
    Jyotsna Joshi
    Mathilde Poyet
    Mathieu Groussin
    Rajesh M. Rajbhandari
    Dibesh B. Karmacharya
    Scientific Reports, 15 (1)
  • [26] HORIZONTAL GENE TRANSFER OF ANTIBIOTIC RESISTANCE GENES IN COMMENSAL ESCHERICHIA COLI FROM REMOTE COMMUNITIES
    Trueba, Gabriel A.
    Segovia, Rosana
    Cevallos, William
    Ponce, Karina
    Kakabadse, Dimitri
    Zhang, Lixin
    Marrs, Carl F.
    Foxmanl, Betsy
    Eisenberg, Joseph
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2008, 79 (06): : 122 - 122
  • [27] Tire wear particles enhance horizontal gene transfer of antibiotic resistance genes in aquatic ecosystems
    Jaffer, Yousuf Dar
    Monikh, Fazel Abdolahpur
    Uli, Kluemper
    Grossart, Hans-Peter
    ENVIRONMENTAL RESEARCH, 2024, 263
  • [28] Surface plasma induced elimination of antibiotic-resistant Escherichia coli and resistance genes: Antibiotic resistance, horizontal gene transfer, and mechanisms
    Song, Ruiying
    Li, Hu
    Kang, Zhao
    Zhong, Rongwei
    Wang, Yangyang
    Zhang, Ying
    Qu, Guangzhou
    Wang, Tiecheng
    SEPARATION AND PURIFICATION TECHNOLOGY, 2021, 275
  • [29] Surface plasma induced elimination of antibiotic-resistant Escherichia coli and resistance genes: Antibiotic resistance, horizontal gene transfer, and mechanisms
    Song, Ruiying
    Li, Hu
    Kang, Zhao
    Zhong, Rongwei
    Wang, Yangyang
    Zhang, Ying
    Qu, Guangzhou
    Wang, Tiecheng
    Separation and Purification Technology, 2021, 275
  • [30] Functions predict horizontal gene transfer and the emergence of antibiotic resistance
    Zhou, Hao
    Beltran, Juan Felipe
    Brito, Ilana Lauren
    SCIENCE ADVANCES, 2021, 7 (43)
12345