Horizontal gene transfer in the human gastrointestinal tract: potential spread of antibiotic resistance genes

被引：355
|
作者：
Huddleston, Jennifer R. [1 ]
机构：
[1] Abilene Christian Univ, Dept Biol, ACU Box 27868, Abilene, TX 79699 USA
来源：
INFECTION AND DRUG RESISTANCE | 2014年 / 7卷
关键词：
gut microbiome; conjugation; natural transformation; transduction; LONG-TERM PERSISTENCE; LACTIC-ACID BACTERIA; ESCHERICHIA-COLI; NATURAL TRANSFORMATION; SOS RESPONSE; AMPICILLIN RESISTANCE; PLASMID TRANSFER; LARGE-INTESTINE; ANIMAL ORIGIN; DNA TRANSPORT;
D O I：
10.2147/IDR.S48820
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Bacterial infections are becoming increasingly difficult to treat due to widespread antibiotic resistance among pathogens. This review aims to give an overview of the major horizontal transfer mechanisms and their evolution and then demonstrate the human lower gastrointestinal tract as an environment in which horizontal gene transfer of resistance determinants occurs. Finally, implications for antibiotic usage and the development of resistant infections and persistence of antibiotic resistance genes in populations as a result of horizontal gene transfer in the large intestine will be discussed.
引用
收藏
页码：167 / 176
页数：10
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