Stroke in patients with sickle cell disease

被引：0

作者：

Webb, Jennifer ^{[1
,2
]}

Kwiatkowski, Janet L. ^{[1
,2
]}

机构：

[1] Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

EXPERT REVIEW OF HEMATOLOGY | 2013年 / 6卷 / 03期

关键词：

cerebrovascular accident; chronic transfusion therapy; review; sickle cell anemia; stroke; TRANSCRANIAL DOPPLER ULTRASONOGRAPHY; CORD BLOOD TRANSPLANTATION; SILENT CEREBRAL INFARCTS; BONE-MARROW-TRANSPLANTATION; MAGNETIC-RESONANCE ANGIOGRAPHY; CENTRAL-NERVOUS-SYSTEM; MIXED HEMATOPOIETIC CHIMERISM; REDUCE IRON OVERLOAD; TRANSFUSION THERAPY; RECURRENT STROKE;

D O I：

10.1586/EHM.13.25

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stroke is a significant cause of morbidity and mortality in children and adults with sickle cell disease. Great advances in the past couple of decades have enabled identification and treatment of children at risk of stroke, with a resultant dramatic reduction in stroke incidence in children. However, prevention and treatment of silent cerebral infarcts remain a challenge. This article reviews our current understanding of the epidemiology, risk factors and pathophysiology of small and large vessel disease with a focus on pediatric patients. The presentation and acute management of stroke in patients with sickle cell disease are discussed. Current recommendations for primary and secondary stroke prevention, as well as ongoing research studies and potential new therapies are reviewed.

引用

页码：301 / 316

页数：16

共 50 条

[31] Childhood stroke in sickle cell disease in Nigeria
Lagunju, Ikeoluwa A.
Brown, Biobele J.
Famosaya, Abimbola A.
[J]. JOURNAL OF PEDIATRIC NEUROLOGY, 2011, 9 (01) : 49 - 53
[32] Neurological PRESentations in Sickle Cell Patients Are Not Always Stroke: A Review of Posterior Reversible Encephalopathy Syndrome in Sickle Cell Disease
Solh, Ziad
Taccone, Michael S.
Marin, Samantha
Athale, Uma
Breakey, Vicky R.
[J]. PEDIATRIC BLOOD & CANCER, 2016, 63 (06) : 983 - 989
[33] Therapy Insight: stroke risk and its management in patients with sickle cell disease
Fenella J Kirkham
[J]. Nature Clinical Practice Neurology, 2007, 3 : 264 - 278
[34] Therapy Insight: stroke risk and its management in patients with sickle cell disease
Kirkham, Fenella J.
[J]. NATURE CLINICAL PRACTICE NEUROLOGY, 2007, 3 (05): : 264 - 278
[35] Impact of Human Leukocyte Antigen on the Risk of Stroke in Patients with Sickle Cell Disease
Al-Harrasi, Huda
Al-Khabori, Murtadha
Al-Kindi, Salam
Wali, Yasser Ahmed Mohamed Soliman
Al Huneini, Mohamed
Al-Riyami, Hamad
[J]. BLOOD, 2019, 134
[36] Trends in Hospital Admissions for Stroke Among Patients With Sickle Cell Disease.
Esenwa, Charles
Lekoubou, Alain
Bishu, Kinfe
Ovbiagele, Bruce
[J]. STROKE, 2019, 50
[37] Genetic Modifiers of Stroke in Patients with Sickle Cell Disease-A Scoping Review
Oni, Morohuntodun O.
Brito, Miguel
Rotman, Chloe
Archer, Natasha M.
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (12)
[38] Enhancing Access to Stroke Neurology Care for Patients With Sickle Cell Disease.
Lara-Angulo, Melissa
Molokie, Robert
Testai, Fernando D.
[J]. STROKE, 2019, 50
[39] Characteristics and outcomes of stroke hospitalizations in patients with sickle cell disease and moyamoya syndrome
Rallo, Michael S.
Akel, Omar
Kalakoti, Piyush
Sun, Hai
[J]. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2022, 31 (10):
[40] Stroke in sickle cell disease patients: transcranial Doppler and magnetic resonance imaging
Bernaudin, Francoise
Verlhac, Suzanne
[J]. HEMATOLOGIE, 2008, 14 (01): : 25 - 35

← 1 2 3 4 5 →