Stroke in patients with sickle cell disease

被引：0

作者：

Webb, Jennifer ^{[1
,2
]}

Kwiatkowski, Janet L. ^{[1
,2
]}

机构：

[1] Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

EXPERT REVIEW OF HEMATOLOGY | 2013年 / 6卷 / 03期

关键词：

cerebrovascular accident; chronic transfusion therapy; review; sickle cell anemia; stroke; TRANSCRANIAL DOPPLER ULTRASONOGRAPHY; CORD BLOOD TRANSPLANTATION; SILENT CEREBRAL INFARCTS; BONE-MARROW-TRANSPLANTATION; MAGNETIC-RESONANCE ANGIOGRAPHY; CENTRAL-NERVOUS-SYSTEM; MIXED HEMATOPOIETIC CHIMERISM; REDUCE IRON OVERLOAD; TRANSFUSION THERAPY; RECURRENT STROKE;

D O I：

10.1586/EHM.13.25

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stroke is a significant cause of morbidity and mortality in children and adults with sickle cell disease. Great advances in the past couple of decades have enabled identification and treatment of children at risk of stroke, with a resultant dramatic reduction in stroke incidence in children. However, prevention and treatment of silent cerebral infarcts remain a challenge. This article reviews our current understanding of the epidemiology, risk factors and pathophysiology of small and large vessel disease with a focus on pediatric patients. The presentation and acute management of stroke in patients with sickle cell disease are discussed. Current recommendations for primary and secondary stroke prevention, as well as ongoing research studies and potential new therapies are reviewed.

引用

页码：301 / 316

页数：16

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