Developing long-acting growth hormone formulations

被引：27
|
作者：
Cawley, Pippa [1 ]
Wilkinson, Ian [1 ]
Ross, Richard J. [1 ]
机构：
[1] Univ Sheffield, Acad Unit Diabet Endocrinol & Reprod, Sheffield S10 2RX, S Yorkshire, England
来源：
CLINICAL ENDOCRINOLOGY | 2013年 / 79卷 / 03期
关键词：
PREPARATION NUTROPIN DEPOT; GH PREPARATION; PHARMACODYNAMIC CHARACTERISTICS; FACTOR-I; PHARMACOKINETICS; CHILDREN; EFFICACY; LB03002; FUSION; SAFETY;
D O I：
10.1111/cen.12240
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Daily recombinant growth hormone (GH) restores normal growth and body composition in GH-deficient children and adults; however, daily injections are inconvenient and can be distressing for some children. On top of this compliance is a problem in up to 75% of children. Developing long-acting GH formulations has proved challenging, and questions remain regarding safety and efficacy. In this review, we focus on the rationale for generating long-acting GH agonists and the technologies being developed to deliver prolonged exposure to GH.
引用
收藏
页码：305 / 309
页数：5
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