RNA-guided genome editing a la carte

被引：11
|
作者：
Horvath, Philippe [1 ]
Barrangou, Rodolphe [2 ]
机构：
[1] DuPont Nutr & Hlth, F-86220 Dange St Romain, France
[2] DuPont Nutr & Hlth, Madison, WI 53716 USA
来源：
CELL RESEARCH | 2013年 / 23卷 / 06期
关键词：
IMMUNE-SYSTEM; CRISPR/CAS; DNA; BACTERIA;
D O I：
10.1038/cr.2013.39
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Two recent papers in Science illustrate how the prokaryotic CRISPR-Cas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated molecular tool for next-generation human genome editing. The versatile Cas9 RNA-guided endonuclease can be readily reprogrammed using customizable small RNAs for sequence-specific single- or double-stranded DNA cleavage. © 2013 IBCB, SIBS, CAS All rights reserved.
引用
收藏
页码：733 / 734
页数：2
相关论文
共 50 条
  • [21] Reversing the Central Dogma: RNA-guided control of DNA in epigenetics and genome editing
    Chang, Howard Y.
    Qi, Lei S.
    MOLECULAR CELL, 2023, 83 (03) : 442 - 451
  • [22] CRISPR RNA-guided Genome Editing in Human Stem Cells, Animals, and Plants
    Kim, J.
    PHYTOPATHOLOGY, 2016, 106 (12) : 176 - 176
  • [23] Dimeric CRISPR RNA-guided Fokl nucleases for highly specific genome editing
    Tsai, Shengdar Q.
    Wyvekens, Nicolas
    Khayter, Cyd
    Foden, Jennifer A.
    Thapar, Vishal
    Reyon, Deepak
    Goodwin, Mathew J.
    Aryee, Martin J.
    Joung, J. Keith
    NATURE BIOTECHNOLOGY, 2014, 32 (06) : 569 - +
  • [24] High Precision Genome Editing by RNA-Guided CRISPR Cas9
    Hsu, Patrick D.
    Ran, Fei Ann
    Scott, David A.
    Lin, Chie-yu
    Gootenberg, Jonathan S.
    Konermann, Silvana
    Zhang, Feng
    MOLECULAR THERAPY, 2014, 22 : S216 - S216
  • [25] Highly efficient RNA-guided base editing in rabbit
    Zhiquan Liu
    Mao Chen
    Siyu Chen
    Jichao Deng
    Yuning Song
    Liangxue Lai
    Zhanjun Li
    Nature Communications, 9
  • [26] Highly efficient RNA-guided base editing in rabbit
    Liu, Zhiquan
    Chen, Mao
    Chen, Siyu
    Deng, Jichao
    Song, Yuning
    Lai, Liangxue
    Li, Zhanjun
    NATURE COMMUNICATIONS, 2018, 9
  • [27] Class 2 CRISPR–Cas RNA-guided endonucleases: Swiss Army knives of genome editing
    Stefano Stella
    Pablo Alcón
    Guillermo Montoya
    Nature Structural & Molecular Biology, 2017, 24 : 882 - 892
  • [28] RNA-guided gene editing of the murine gammaherpesvirus 68 genome reduces infectious virus production
    Foreman, Hui-Chen Chang
    Kirillov, Varvara
    Paniccia, Gabrielle
    Catalano, Demetra
    Andrunik, Trevor
    Gupta, Swati
    Krug, Laurie T.
    Zhang, Yue
    PLOS ONE, 2021, 16 (06):
  • [29] RNA-Guided Adenosine Deaminases: Advances and Challenges for Therapeutic RNA Editing
    Chen, Genghao
    Katrekar, Dhruva
    Mali, Prashant
    BIOCHEMISTRY, 2019, 58 (15) : 1947 - 1957
  • [30] Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
    Ran, F. Ann
    Hsu, Patrick D.
    Lin, Chie-Yu
    Gootenberg, Jonathan S.
    Konermann, Silvana
    Trevino, Alexandro E.
    Scott, David A.
    Inoue, Azusa
    Matoba, Shogo
    Zhang, Yi
    Zhang, Feng
    CELL, 2013, 154 (06) : 1380 - 1389
12345