Deriving dopaminergic neurons for clinical use. A practical approach

被引：38
|
作者：
Gonzalez, Rodolfo [1 ]
Garitaonandia, Ibon [1 ]
Abramihina, Tatiana [1 ]
Wambua, Gerald K. [1 ]
Ostrowska, Alina [1 ]
Brock, Mathew [2 ]
Noskov, Alexander [1 ]
Boscolo, Francesca S. [3 ,4 ]
Craw, John S. [1 ]
Laurent, Louise C. [4 ]
Snyder, Evan Y. [5 ]
Semechkin, Ruslan A. [1 ]
机构：
[1] Int Stem Cell Corp, Carlsbad, CA 92008 USA
[2] Axion Biosyst, Atlanta, GA 30332 USA
[3] Scripps Res Inst, Dept Physiol Chem, Ctr Regenerat Med, La Jolla, CA 92037 USA
[4] Univ Calif San Diego, Dept Reprod Med, San Diego, CA 92035 USA
[5] Sanford Burnham Med Res Inst, Stem Cell & Regenerat Program, La Jolla, CA 92037 USA
来源：
SCIENTIFIC REPORTS | 2013年 / 3卷
关键词：
PLURIPOTENT STEM-CELLS; DIFFERENTIATION;
D O I：
10.1038/srep01463
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients.
引用
收藏
页数：5
相关论文
共 50 条
  • [31] Glucocorticoids and multiple myeloma: mechanism of action, resistance and clinical use.
    Paule, B
    Clerc, D
    Brion, N
    ANNALES DE MEDECINE INTERNE, 1998, 149 (08): : 502 - 507
  • [32] Andexanet alfa - Recommendations for clinical use. Multidisciplinary experts' standpoint
    Kubica, Jacek
    Adamski, Piotr
    Gajda, Robert
    Gasior, Mariusz
    Gierlotka, Marek
    Gil, Robert
    Jaguszewski, Milosz
    Kubica, Aldona
    Kuliczkowski, Wiktor
    Kurek, Krzysztof
    Ladny, Jerzy Robert
    Michalski, Piotr
    Navarese, Eliano Pio
    Niezgoda, Piotr
    Ostrowska, Malgorzata
    Tycinska, Agnieszka
    CARDIOLOGY JOURNAL, 2023, 30 (04) : 502 - 505
  • [33] Colorectal Cancer and Microbiota Modulation for Clinical Use. A Systematic Review
    Madrigal-Matute, Julio
    Escandell, Sara Banon
    NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2022, 75 (01): : 123 - 139
  • [34] Cognitive map construction and use. A parallel distributed processing approach
    Chrisley, R.L.
    Proceedings of the Connectionist Models Summer School, 1990,
  • [35] Improvement of gene transfer into human T lymphocytes for clinical use.
    Ayuketang, FA
    Li, ZX
    Fehse, B
    Schade, UM
    Zander, AR
    BONE MARROW TRANSPLANTATION, 1999, 23 : S84 - S84
  • [36] The impact of clinical pharmacist and ID intervention in rationalisation of antimicrobial use.
    Al-Somai, Niaz
    Al-Quteimat, Osama
    Al-Muhur, Mohammed
    Hamza, Nashaat
    PHARMACOTHERAPY, 2014, 34 (06): : E84 - E84
  • [37] Urethral dilations: a traditional treatment still in use. Clinical case
    Barcina Valle, Agueda
    REVISTA ROL DE ENFERMERIA, 2023, 46 (03): : 22 - 26
  • [38] Clinical Psychopharmacology: A Practical Approach
    Lozano, Abby Ornelas
    AMERICAN JOURNAL OF PSYCHIATRY, 2014, 171 (04): : 471 - 471
  • [39] A practical approach to low protein diets in Sweden– 45 years of clinical use
    Sintra Eyre
    Gerd Faxén-Irving
    Per-Ola Attman
    Marie Evans
    Karin Windahl
    Sigrid Wegener
    Charlotte Andersén
    Karin Nykvist-Raanaes
    Sara Einemo
    Juan-Jesus Carrero
    BMC Nephrology, 17
  • [40] The impact ofjellyfish on recreational beach use. An approach from a risk perspective
    Prados, Francisco Jose Cantarero
    Rosello, Ana de la Fuente
    Lopez, Juan Jesus Bellido
    CUADERNOS GEOGRAFICOS, 2023, 62 (01): : 300 - 318
12345