Deriving dopaminergic neurons for clinical use. A practical approach

被引：38

作者：

Gonzalez, Rodolfo ^{[1
]}

Garitaonandia, Ibon ^{[1
]}

Abramihina, Tatiana ^{[1
]}

Wambua, Gerald K. ^{[1
]}

Ostrowska, Alina ^{[1
]}

Brock, Mathew ^{[2
]}

Noskov, Alexander ^{[1
]}

Boscolo, Francesca S. ^{[3
,4
]}

Craw, John S. ^{[1
]}

Laurent, Louise C. ^{[4
]}

Snyder, Evan Y. ^{[5
]}

Semechkin, Ruslan A. ^{[1
]}

机构：

[1] Int Stem Cell Corp, Carlsbad, CA 92008 USA

[2] Axion Biosyst, Atlanta, GA 30332 USA

[3] Scripps Res Inst, Dept Physiol Chem, Ctr Regenerat Med, La Jolla, CA 92037 USA

[4] Univ Calif San Diego, Dept Reprod Med, San Diego, CA 92035 USA

[5] Sanford Burnham Med Res Inst, Stem Cell & Regenerat Program, La Jolla, CA 92037 USA

来源：

SCIENTIFIC REPORTS | 2013年 / 3卷

关键词：

PLURIPOTENT STEM-CELLS; DIFFERENTIATION;

D O I：

10.1038/srep01463

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients.

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