High Resolution Crystal Structures of Translocator Protein 18 kDa (TSPO) Reveal Ligand Binding Sites and Effects of a Human Single Polymorphism

被引：0
|
作者：
Ferguson-Miller, Shelagh [1 ]
Li, Fei [1 ]
Liu, Jian [1 ]
Zheng, Yi [1 ]
Valls, Lance [1 ]
Garavito, R. Michael [1 ]
机构：
[1] Michigan State Univ, Biochem Mol Biol, E Lansing, MI 48824 USA
来源：
BIOPHYSICAL JOURNAL | 2015年 / 108卷 / 02期
关键词：
D O I：
10.1016/j.bpj.2014.11.030
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
13-Subg
引用
收藏
页码：3A / 3A
页数：1
相关论文
共 50 条
  • [41] NEUROPROTECTIVE EFFECTS OF A LIGAND OF TRANSLOCATOR PROTEIN-18kDa (Ro5-4864) IN EXPERIMENTAL DIABETIC NEUROPATHY
    Giatti, S.
    Pesaresi, M.
    Cavaletti, G.
    Bianchi, R.
    Carozzi, V.
    Lombardi, R.
    Maschi, O.
    Lauria, G.
    Garcia-Segura, L. M.
    Caruso, D.
    Melcangi, R. C.
    NEUROSCIENCE, 2009, 164 (02) : 520 - 529
  • [42] Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [18F]FEDAA1106: a human whole-body PET study
    Takano, Akihiro
    Gulyas, Balazs
    Varrone, Andrea
    Karlsson, Per
    Sjoholm, Nils
    Larsson, Stig
    Jonsson, Cathrine
    Odh, Richard
    Sparks, Richard
    Al Tawil, Nabil
    Hoffmann, Anja
    Zimmermann, Torsten
    Thiele, Andrea
    Halldin, Christer
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2011, 38 (11) : 2058 - 2065
  • [43] Inhalation of cigarette smoke decreases the binding of [18F]DPA-714 to 18 kDa translocator protein (TSPO) in several tissues: a PET study in baboons.
    Saba, W.
    Peyronneau, M.
    Goutal, S.
    Damont, A.
    Dolle, F.
    Tournier, N.
    Valette, H.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 39 : S412 - S412
  • [44] Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [18F]FEDAA1106: a human whole-body PET study
    Akihiro Takano
    Balázs Gulyás
    Andrea Varrone
    Per Karlsson
    Nils Sjoholm
    Stig Larsson
    Cathrine Jonsson
    Richard Odh
    Richard Sparks
    Nabil Al Tawil
    Anja Hoffmann
    Torsten Zimmermann
    Andrea Thiele
    Christer Halldin
    European Journal of Nuclear Medicine and Molecular Imaging, 2011, 38 : 2058 - 2065
  • [45] Propofol Decreases In Vivo Binding of 11C-PBR28 to Translocator Protein (18 kDa) in the Human Brain
    Hines, Christina S.
    Fujita, Masahiro
    Zoghbi, Sami S.
    Kim, Jin Su
    Quezado, Zenaide
    Herscovitch, Peter
    Miao, Ning
    Araneta, Maria D. Ferraris
    Morse, Cheryl
    Pike, Victor W.
    Labovsky, Julia
    Innis, Robert B.
    JOURNAL OF NUCLEAR MEDICINE, 2013, 54 (01) : 64 - 69
  • [46] Dissociation of endocrine responses to the Trier Social Stress Test in Virtual Reality (VR-TSST) by the benzodiazepine alprazolam and the translocator protein 18 kDa (TSPO) ligand etifoxine
    Bahr, Lisa-Marie
    Maurer, Franziska
    Weigl, Johannes
    Weber, Kevin
    Melchner, Doris
    Doerfelt, Anett
    Wechsler, Theresa F.
    Bauer, Olivia
    Reinders, Joerg
    Milenkovic, Vladimir M.
    Wetzel, Christian H.
    Wetter, Thomas C.
    Rupprecht, Rainer
    Muehlberger, Andreas
    Nothdurfter, Caroline
    PSYCHONEUROENDOCRINOLOGY, 2021, 124
  • [47] Confirmation of specific binding of the 18 kDa translocator protein (TSPO) radioligand [18F]GE-180: a blocking study using XDB173 in multiple sclerosis
    Sridharan, S.
    Raffel, J.
    Nandoskar, A.
    Record, C.
    Brooks, D.
    Owen, D.
    Sharp, D.
    Muraro, P.
    Gunn, R.
    Nicholas, R.
    MULTIPLE SCLEROSIS JOURNAL, 2018, 24 : 421 - 422
  • [48] FTSite: high accuracy detection of ligand binding sites on unbound protein structures
    Ngan, Chi-Ho
    Hall, David R.
    Zerbe, Brandon
    Grove, Laurie E.
    Kozakov, Dima
    Vajda, Sandor
    BIOINFORMATICS, 2012, 28 (02) : 286 - 287
  • [49] Antidepressant, anxiolytic and anti-PTSD effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa)
    Zhang, Li-ming
    Zhao, Nan
    Qiu, Zhi-kun
    Guo, Wen-zhi
    Jin, Zeng-liang
    Zhou, Wen-wen
    Chen, Hong-xia
    Zhang, You-zhi
    Li, Yun-feng
    ACTA PHARMACOLOGICA SINICA, 2013, 34 : 122 - 122
  • [50] Antidepressant-Like and Anxiolytic-Like Effects of ZBD-2, a Novel Ligand for the Translocator Protein (18 kDa)
    Wang, Dong-sheng
    Han, Jing
    Li, Shuo
    Sun, Ting
    Guo, Yan-yan
    Kang, Wen-bo
    Tian, Zhen
    Zhao, Jian-ning
    Liu, Gang
    Liu, Shui-bing
    Zhao, Ming-gao
    NEUROMOLECULAR MEDICINE, 2017, 19 (01) : 57 - 68
12345