Synthesis, characterization, in silico studies and in vitro biological evaluation of isoniazid-hydrazone complexes

被引：15
|
作者：
Rajan, M. P. Ramya [1 ,2 ]
Rathikha, Ramaswamy [2 ]
Nithyabalaji, Rajendran [1 ]
Sribalan, Rajendran [3 ]
机构：
[1] SRM Valliammai Engn Coll, Dept Phys, Kattankulathur, Tamil Nadu, India
[2] Presidency Coll Autonomous, PG & Res Dept Phys, Chennai 600005, Tamil Nadu, India
[3] Biochem Innovat Lab, Tindivanam, Tamil Nadu, India
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2020年 / 1216卷
关键词：
Isoniazid; Anti-inflammatory; Antidiabetic; Molecular docking; DFT studies; MYCOBACTERIUM-TUBERCULOSIS; ANALGESIC ACTIVITY; MOLECULAR DOCKING; ALPHA-AMYLASE; RELEVANT; CURCUMIN; DESIGN;
D O I：
10.1016/j.molstruc.2020.128297
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Isoniazid-hydrazone complexes (IHCs) were synthesized and thoroughly characterized by FT-IR, H-1 NMR and C-13 NMR spectroscopic techniques. The anti-in fl ammatory and antidiabetic activities were tested for the IHCs using protein denaturation methods and the a-amylase inhibitory method. The molecular modeling studies for IHCs were investigated and their molecular parameters were calculated using Density Functional Theory methods. The IHCs showed lower band gap and higher electrophilicity index values. Further, molecular docking studies were investigated against the a-amylase enzyme to compare the experimental results. The isoniazid hydrazone-salicylic acid complex (3c) showed fi ve hydrogen bonding interactions with amino acid residues of the alpha-amylase enzyme (1HNY). (c) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页数：9
相关论文
共 50 条
  • [31] Palladium(II) complexes of 5-substituted isatin thiosemicarbazones: Synthesis, spectroscopic characterization, biological evaluation and in silico docking studies
    Munikumari, Gandham
    Konakanchi, Ramaiah
    Nishtala, Venkata Bharat
    Ramesh, Gondru
    Kotha, Laxma Reddy
    Chandrasekhar, K. B.
    Ramachandraiah, Chennuru
    SYNTHETIC COMMUNICATIONS, 2019, 49 (01) : 146 - 158
  • [32] Synthesis, characterization, in-silico, and in-vitro biological studies of Cu(II), Zn(II) complexes of semicarbazone, thiosemicarbazone derivatives of dehydrozingerone
    Muleta, Fekadu
    Desalegn, Tegene
    Eswaramoorthy, Rajalakshmanan
    Garg, Ankita
    JOURNAL OF MOLECULAR STRUCTURE, 2022, 1268
  • [33] Lanthanide Complexes of Substituted β-Diketone Hydrazone Derivatives: Synthesis, Characterization, and Biological Activities
    Hegazy, W. H.
    Al-Motawaa, I. H.
    BIOINORGANIC CHEMISTRY AND APPLICATIONS, 2011, 2011
  • [34] Synthesis, Characterization, and Biological Activities of Lanthanide(III) Complexes of β-Diketone Hydrazone Derivatives
    Hegazy, W. H.
    Al-Motawaa, I. H.
    SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY, 2011, 41 (09) : 1172 - 1181
  • [35] Synthesis, characterization, thermal behavior and biological studies of VOIV and MoO2VI complexes of hydrazone ligand
    Bhaskar, R. S.
    Salunkhe, N. G.
    Yaul, A. R.
    Aswar, A. S.
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2016, 93 (05) : 489 - 494
  • [36] Vanillin Derived Hydrazone Ligands and Their Transition Metal Complexes: Synthesis, Characterization, Biological Activity and Molecular Docking Studies
    Devi, Jai
    Arora, Tanisha
    JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS, 2025,
  • [37] Synthesis, structural characterization, DFT studies and biological activity of Cu(II) and Ni(II) complexes of novel hydrazone
    El-Sherif, Ahmed A.
    Fetoh, Ahmed
    Abdulhamed, Yasir Kh.
    Abu El-Reash, Gaber M.
    INORGANICA CHIMICA ACTA, 2018, 480 : 1 - 15
  • [38] Synthesis, spectroscopic, in vitro, in vivo biological evaluation, and in silico docking analysis of new meloxicam metal complexes
    Samra, Malka M.
    Basra, Muhammad Asim Raza
    APPLIED ORGANOMETALLIC CHEMISTRY, 2023, 37 (03)
  • [39] Synthesis, characterization and biological activity evaluation of novel Pd(II) and Pt(II) complexes with heterocyclic hydrazone ligands
    Filipovic, N. R.
    Todorovic, T. R.
    Sladic, D. M.
    Novakovic, I. T.
    Jeremic, D. A.
    Andjelkovic, K. K.
    RESEARCH TRENDS IN CONTEMPORARY MATERIALS SCIENCE, 2007, 555 : 423 - +
  • [40] Design, synthesis, structure and biological evaluation of new palladium(II) hydrazone complexes
    Ayyannan, Ganesan
    Mohanraj, Maruthachalam
    Raja, Gunasekaran
    Bhuvanesh, Nanjan
    Nandhakumar, Raju
    Jayabalakrishnan, Chinnasamy
    INORGANICA CHIMICA ACTA, 2016, 453 : 562 - 573
12345