Vaccines against Tuberculosis: Where Are We and Where Do We Need to Go?

被引：348
|
作者：
Ottenhoff, Tom H. M. [1 ]
Kaufmann, Stefan H. E. [2 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Infect Dis, Leiden, Netherlands
[2] Max Planck Inst Infect Biol, Deptartment Immunol, Berlin, Germany
来源：
PLOS PATHOGENS | 2012年 / 8卷 / 05期
基金：
比尔及梅琳达.盖茨基金会;
关键词：
T-CELL RESPONSES; HEPARIN-BINDING HEMAGGLUTININ; CALMETTE-GUERIN VACCINATION; DRUG-RESISTANT TUBERCULOSIS; HOST-PATHOGEN INTERACTIONS; MYCOBACTERIUM-BOVIS BCG; IMMUNE-RESPONSE; LATENT INFECTION; EXTRAPULMONARY DISSEMINATION; POLYFUNCTIONAL CD4(+);
D O I：
10.1371/journal.ppat.1002607
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In this review we discuss recent progress in the development, testing, and clinical evaluation of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has been made in TB vaccine research and development: from a pipeline virtually empty of new TB candidate vaccines in the early 1990s, to an era in which a dozen novel TB vaccine candidates have been and are being evaluated in human clinical trials. In addition, innovative approaches are being pursued to further improve existing vaccines, as well as discover new ones. Thus, there is good reason for optimism in the field of TB vaccines that it will be possible to develop better vaccines than BCG, which is still the only vaccine available against TB.
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页数：12
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