Shvo's catalyst in chemoenzymatic dynamic kinetic resolution of amines - inner or outer sphere mechanism

被引：9

作者：

Vaz, Boniek G. ^{[1
]}

Milagre, Cintia D. F. ^{[2
]}

Eberlin, Marcos N. ^{[3
]}

Milagre, Humberto M. S. ^{[2
]}

机构：

[1] Univ Fed Goias, Inst Chem, BR-74001970 Goiania, Go, Brazil

[2] Univ Estadual Paulista UNESP, Inst Chem, Dept Organ Chem, BR-14800060 Araraquara, SP, Brazil

[3] Univ Campinas UNICAMP, ThoMSon Mass Spectrometry Lab, Inst Chem, BR-13084971 Campinas, SP, Brazil

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 39期

基金：

巴西圣保罗研究基金会;

关键词：

HYDROXYCYCLOPENTADIENYL RUTHENIUM HYDRIDE; ELECTROSPRAY-IONIZATION MASS; ENANTIOMERICALLY PURE AMINES; HYDROGEN-TRANSFER REACTIONS; CONCERTED TRANSFER; GAS-PHASE; SPECTROMETRY; COMPLEX; IMINES; COORDINATION;

D O I：

10.1039/c3ob41318g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Evidence is provided for the inner-sphere mechanism with actual metal coordination of the racemic amine in the crucial hydrogen transfer step promoted by Shvo's catalyst of the chemoenzymatic dynamic kinetic resolution (DKR) of amines. Key intermediates involved in this H-transfer step were intercepted and continuously monitored by electrospray ionization mass spectrometry (ESI-MS) and characterized by their dissociation chemistries via ESI-MS/MS.

引用

页码：6695 / 6698

页数：4

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