The risk of cardiovascular disease associated with proteinuria in renal transplant patients

被引：95

作者：

Fernández-Fresnedo, G ^{[1
]}

Escallada, R ^{[1
]}

Rodrigo, E ^{[1
]}

De Francisco, ALM ^{[1
]}

Cotorruelo, JG ^{[1
]}

De Castro, SS ^{[1
]}

Zubimendi, JA ^{[1
]}

Ruiz, JC ^{[1
]}

Arias, M ^{[1
]}

机构：

[1] Hosp Univ Marques Valdecilla, Serv Nefrol, INSALUD, Santander 39008, Spain

来源：

TRANSPLANTATION | 2002年 / 73卷 / 08期

关键词：

D O I：

10.1097/00007890-200204270-00028

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Proteinuria in the general population has been shown to be associated with cardiovascular disease, which is the main cause of death in renal transplantation. We investigated the effect of proteinuria on cardiovascular disease after renal transplantation in 532 renal transplant patients with functioning grafts for more than 1 year. Patients were classified into two groups depending on the presence of persistent proteinuria. We analyzed graft and patient survival, post-transplantation cardiovascular disease, and main causes of graft loss and death. Five- and 10-year graft and patient survival rates were lower in the group with proteinuria. The main cause of death was vascular disease in both groups. The presence of post-transplantation cardiovascular disease was higher in the group with proteinuria. Persistent proteinuria was associated with graft loss (RR=4.18), patient death (RR=1.92), and cardiovascular disease (RR=2.45). In conclusion, persistent proteinuria was an independent risk factor for increased cardiovascular morbidity and mortality in renal transplant patients.

引用

页码：1345 / 1348

页数：4

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