Mitochondrial Quality Control: Decommissioning Power Plants in Neurodegenerative Diseases

被引:2
|
作者
Mukherjee, Rukmini [1 ]
Chakrabarti, Oishee [1 ]
机构
[1] Saha Inst Nucl Phys, Struct Genom Div, Kolkata 700064, India
来源
SCIENTIFIC WORLD JOURNAL | 2013年
关键词
DYNAMIN-RELATED PROTEIN-1; OXIDATIVE STRESS; REACTIVE OXYGEN; AUTOPHAGIC DEGRADATION; CELL-DEATH; PROTEASE; FISSION; PARKIN; MITOPHAGY; RECEPTOR;
D O I
10.1155/2013/180759
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The cell has an intricate quality control system to protect its mitochondria from oxidative stress. This surveillance system is multi-tiered and comprises molecules that are present inside the mitochondria, in the cytosol, and in other organelles like the nucleus and endoplasmic reticulum. These molecules cross talk with each other and protect the mitochondria from oxidative stress. Oxidative stress is a fundamental part of early disease pathogenesis of neurodegenerative diseases. These disorders also damage the cellular quality control machinery that protects the cell against oxidative stress. This exacerbates the oxidative damage and causes extensive neuronal cell death that is characteristic of neurodegeneration.
引用
收藏
页数:11
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