VE-Cadherin and Endothelial Adherens Junctions: Active Guardians of Vascular Integrity

被引：625
|
作者：
Giannotta, Monica [1 ]
Trani, Marianna [1 ]
Dejana, Elisabetta [1 ,2 ]
机构：
[1] FIRC Inst Mol Oncol, I-20129 Milan, Italy
[2] Univ Milan, Dept Biosci, I-20122 Milan, Italy
来源：
DEVELOPMENTAL CELL | 2013年 / 26卷 / 05期
基金：
欧洲研究理事会;
关键词：
CELL-CELL-ADHESION; ALPHA-CATENIN; BETA-CATENIN; BARRIER FUNCTION; GROWTH-FACTOR; RHO-KINASE; N-CADHERIN; LEUKOCYTE EXTRAVASATION; MOLECULAR-ORGANIZATION; TIGHT JUNCTIONS;
D O I：
10.1016/j.devcel.2013.08.020
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
VE-cadherin is a component of endothelial cell-to-cell adherens junctions, and it has a key role in the maintenance of vascular integrity. During embryo development, VE-cadherin is required for the organization of a stable vascular system, and in the adult it controls vascular permeability and inhibits unrestrained vascular growth. The mechanisms of action of VE-cadherin are complex and include reshaping and organization of the endothelial cell cytoskeleton and modulation of gene transcription. Here we review some of the most important pathways through which VE-cadherin modulates vascular homeostasis and discuss the emerging concepts in the overall biological role of this protein.
引用
收藏
页码：441 / 454
页数：14
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