The Non-Canonical IκB Kinases IKKε and TBK1 as Potential Targets for the Development of Novel Therapeutic Drugs

被引：4

作者：

Niederberger, E. ^{[1
]}

Moeser, C. V. ^{[1
]}

Kynast, K. L. ^{[1
]}

Geisslinger, G. ^{[1
]}

机构：

[1] Univ Frankfurt Klinikum, Pharmazentrum Frankfurt ZAFES, D-60590 Frankfurt, Germany

来源：

CURRENT MOLECULAR MEDICINE | 2013年 / 13卷 / 07期

关键词：

Cancer; IKK epsilon; inflammation; interferon regulatory factor; NF-kappa B; TBK1; INTERFERON REGULATORY FACTOR-3; COLLAGEN-INDUCED ARTHRITIS; TANK-BINDING KINASE-1; TOLL-LIKE RECEPTORS; RHEUMATOID-ARTHRITIS; LIVER DEGENERATION; TRANSCRIPTION FACTORS; INSULIN-RECEPTOR; SYNOVIAL TISSUE; MICE LACKING;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

I kappa B kinase epsilon (IKK epsilon) and TANK-binding kinase 1 (TBK1) are two non-canonical IKKs which are involved in interferon regulatory factor (IRF) as well as nuclear factor kappaB (NF-kappa B) signaling cascades. Both kinases have already been linked to the pathophysiology of several diseases and therefore been suggested as potential promising targets for the development of therapeutic drugs. In this review, we summarize the roles of IKK epsilon and TBK1 in different diseases and outline therapeutic options for modulation of these kinases.

引用

页码：1089 / 1097

页数：9

共 47 条

[41] A non-canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT)
Chen, Li
Lu, Yikai
Zhao, Mengmeng
Xu, Junfang
Wang, Yan
Xu, Qinghua
Cao, Yajuan
Liu, Haipeng
JOURNAL OF GENE MEDICINE, 2024, 26 (01):
[42] G-Quadruplex DNA and Other Non-Canonical B-Form DNA Motifs Influence Productive and Latent HIV-1 Integration and Reactivation Potential
Ajoge, Hannah O.
Kohio, Hinissan P.
Paparisto, Ermela
Coleman, Macon D.
Wong, Kemen
Tom, Sean K.
Bain, Katie L.
Berry, Charles C.
Arts, Eric J.
Barr, Stephen D.
VIRUSES-BASEL, 2022, 14 (11):
[43] P-glycoprotein (ABCB1) expression during breast cancer development is regulated by HuR-dependent loading of miR-19b at non-canonical sites
Thorne, James L.
Battaglia, Sebastiano
Jana, Samir S.
Millican-Slater, Rebecca A.
Smith, Laura
Wastall, Laura
Hughes, Thomas A.
BREAST CANCER RESEARCH AND TREATMENT, 2016, 159 (01) : 188 - 188
[44] Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKε and DDX3
Yu, Shiyan
Chen, Jieliang
Wu, Min
Chen, Hui
Kato, Nobuyuki
Yuan, Zhenghong
JOURNAL OF GENERAL VIROLOGY, 2010, 91 : 2080 - 2090
[45] Investigation of calcineurin B homolgous protein 2 regulation on NHE1. A potential novel therapeutic target to treat non-small cell lung cancer
Anderson, Kristina
Slusser, Andrea
Provost, Joseph
Wallert, Mark
FASEB JOURNAL, 2011, 25
[46] Role of the Transcription Factor Yin Yang 1 and Its Selectively Identified Target Survivin in High-Grade B-Cells Non-Hodgkin Lymphomas: Potential Diagnostic and Therapeutic Targets
Vivarelli, Silvia
Falzone, Luca
Ligresti, Giovanni
Candido, Saverio
Garozzo, Adriana
Magro, Gaetano Giuseppe
Bonavida, Benjamin
Libra, Massimo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (17) : 1 - 26
[47] The development of a modified human IFN-α2b linked to the Fc portion of human IgG1 as a novel potential therapeutic for the treatment of hepatitis C virus infection
Jones, TD
Hanlon, M
Smith, BJ
Heise, CT
Nayee, PD
Sanders, DA
Hamilton, A
Sweet, C
Unitt, E
Alexander, G
Lo, KM
Gillies, SD
Carr, FJ
Baker, MP
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2004, 24 (09): : 560 - 572

← 1 2 3 4 5 →