The Non-Canonical IκB Kinases IKKε and TBK1 as Potential Targets for the Development of Novel Therapeutic Drugs

被引：4
|
作者：
Niederberger, E. [1 ]
Moeser, C. V. [1 ]
Kynast, K. L. [1 ]
Geisslinger, G. [1 ]
机构：
[1] Univ Frankfurt Klinikum, Pharmazentrum Frankfurt ZAFES, D-60590 Frankfurt, Germany
来源：
CURRENT MOLECULAR MEDICINE | 2013年 / 13卷 / 07期
关键词：
Cancer; IKK epsilon; inflammation; interferon regulatory factor; NF-kappa B; TBK1; INTERFERON REGULATORY FACTOR-3; COLLAGEN-INDUCED ARTHRITIS; TANK-BINDING KINASE-1; TOLL-LIKE RECEPTORS; RHEUMATOID-ARTHRITIS; LIVER DEGENERATION; TRANSCRIPTION FACTORS; INSULIN-RECEPTOR; SYNOVIAL TISSUE; MICE LACKING;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
I kappa B kinase epsilon (IKK epsilon) and TANK-binding kinase 1 (TBK1) are two non-canonical IKKs which are involved in interferon regulatory factor (IRF) as well as nuclear factor kappaB (NF-kappa B) signaling cascades. Both kinases have already been linked to the pathophysiology of several diseases and therefore been suggested as potential promising targets for the development of therapeutic drugs. In this review, we summarize the roles of IKK epsilon and TBK1 in different diseases and outline therapeutic options for modulation of these kinases.
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收藏
页码：1089 / 1097
页数：9
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