Objective: To evaluate the variables of cystic renal lesions to predict the renal tumors. Study Design: An observational study. Place and Duration of Study: Urology Department, Ankara Yuksek Ihtisas, Samsun Research and Training Hospitals, Turkey, from January 2013 to June 2017. Methodology: Records of patients with renal cystic lesions were retrospectively evaluated. Preoperative CT results in terms of diameter number and enhancement; and clinical variables such as gender body mass index [(weight (kg)/ height (2)(m)] and smoking status were recorded. Student's t- test and ANOVA were used for determing significance, which was set at p< 0.05. Results: Due to pathology results, all group I patients were benign, 7.9% (3/38) of group II, 31.8% (7/22) of group II- F, 55.3% (21/38) of group III, 69% (40/58) group IV patients were found to be malignant. For clinical factors, obesity and smoking, while for radiological parameters, about 59.3 +/- 11.7 HU enhancement were found to be predictor significant of malignancy (all p<0.05). No significant difference was observed between cystic lesion diameter number or laterality (right/left) and malignancy. Conclusion: Renal cysts have a high malignancy possibility in the patients with history of smoking in the past or actively, high BMI, and preoperative CT with about 59.3 +/- 11.7 HU post-contrast enhancement.