Role of membranes in the activities of antimicrobial cationic peptides

被引：396
|
作者：
Hancock, REW [1 ]
Rozek, A [1 ]
机构：
[1] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada
来源：
FEMS MICROBIOLOGY LETTERS | 2002年 / 206卷 / 02期
关键词：
antimicrobial peptide; cationic peptide; membrane; model membrane; mode of action;
D O I：
10.1016/S0378-1097(01)00480-3
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes. a number of cationic peptides can traverse intact membranes to interact with internal targets. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：143 / 149
页数：7
相关论文
共 50 条
  • [31] Cationic Antimicrobial Peptides in Penaeid Shrimp
    Tassanakajon, Anchalee
    Amparyup, Piti
    Somboonwiwat, Kunlaya
    Supungul, Premruethai
    MARINE BIOTECHNOLOGY, 2010, 12 (05) : 487 - 505
  • [32] Cationic host defense (antimicrobial) peptides
    Brown, KL
    Hancock, REW
    CURRENT OPINION IN IMMUNOLOGY, 2006, 18 (01) : 24 - 30
  • [33] Membrane targeting cationic antimicrobial peptides
    Ciumac, Daniela
    Gong, Haoning
    Hu, Xuzhi
    Lu, Jian Ren
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2019, 537 : 163 - 185
  • [34] The interaction of antimicrobial peptides with membranes
    Travkova, Oksana G.
    Moehwald, Helmuth
    Brezesinski, Gerald
    ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2017, 247 : 521 - 532
  • [35] Antimicrobial peptides: to membranes and beyond
    Marcos, Jose F.
    Gandia, Monica
    EXPERT OPINION ON DRUG DISCOVERY, 2009, 4 (06) : 659 - 671
  • [36] Roles of hydrophobicity and charge distribution of cationic antimicrobial peptides in their interactions with bacterial membranes and biofilm polysaccharides
    Yin, Lois M.
    Edwards, Michelle
    Li, Jessica
    Yip, Christopher M.
    Deber, Charles M.
    BIOPOLYMERS, 2011, 96 (04) : 501 - 501
  • [37] Using liquid crystals to report molecular interactions between cationic antimicrobial peptides and lipid membranes
    Hu, Qiong-Zheng
    Jang, Chang-Hyun
    ANALYST, 2012, 137 (03) : 567 - 570
  • [38] Lipid topology and electrostatic interactions underpin lytic activity of linear cationic antimicrobial peptides in membranes
    Paterson, David J.
    Tassieri, Manlio
    Reboud, Julien
    Wilson, Rab
    Cooper, Jonathan M.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (40) : E8324 - E8332
  • [39] Synthetic Antimicrobial Peptides: I. Antimicrobial Activity of Amphiphilic and Nonamphiphilic Cationic Peptides
    Amirkhanov, N. V.
    Tikunova, N. V.
    Pyshnyi, D. V.
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2018, 44 (05) : 492 - 503
  • [40] The Role of Formyl Peptide Receptors for Immunomodulatory Activities of Antimicrobial Peptides and Peptidomimetics
    Skovbakke, Sarah Line
    Holdfeldt, Andre
    Forsman, Huamei
    Bylund, Johan
    Franzyk, Henrik
    CURRENT PHARMACEUTICAL DESIGN, 2018, 24 (10) : 1100 - 1120
12345