Role of membranes in the activities of antimicrobial cationic peptides

被引：396
|
作者：
Hancock, REW [1 ]
Rozek, A [1 ]
机构：
[1] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada
来源：
FEMS MICROBIOLOGY LETTERS | 2002年 / 206卷 / 02期
关键词：
antimicrobial peptide; cationic peptide; membrane; model membrane; mode of action;
D O I：
10.1016/S0378-1097(01)00480-3
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes. a number of cationic peptides can traverse intact membranes to interact with internal targets. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：143 / 149
页数：7
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