Clean Preparation of Quinolin-2-yl Substituted Ureas in Water

被引：85
|
作者：
Xie, Long-Yong [1 ]
Peng, Sha [1 ]
Liu, Fang [1 ]
Liu, Yan-Fang [1 ]
Sun, Meng [2 ]
Tang, Zi-Long [2 ]
Jiang, Si [3 ]
Cao, Zhong [3 ]
He, Wei-Min [1 ]
机构：
[1] Hunan Univ Sci & Engn, Dept Chem, Yongzhou 425100, Peoples R China
[2] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China
[3] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Hunan, Peoples R China
来源：
ACS SUSTAINABLE CHEMISTRY & ENGINEERING | 2019年 / 7卷 / 07期
关键词：
In water; Quinoline N-oxides; Atom economy; Reusability; Green chemistry; HETEROAROMATIC N-OXIDES; ONE-POT SYNTHESIS; MEDIATED SULFONYLATION; BASE-FREE; METAL; AMINATION; ACTIVATION; MILD; BOND; ALKYNES;
D O I：
10.1021/acssuschemeng.9b00200
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An environmentally-friendly method for the clean preparation of various quinolin-2-yl substituted ureas in water under mild and toxic reagent-, base-, and organic solvent-free conditions was established. In the large-scale synthesis, the products could be rapidly collected via simple filtration and washing with ethanol. The usage of readily available raw materials, 100% atom economy, high yield, and excellent regioselectivity enhanced the practicability of this protocol.
引用
收藏
页码：7193 / 7199
页数：13
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