E4ORF3 requirement for achieving long-term transgene expression from the cytomegalovirus promoter in adenovirus vectors

被引：30

作者：

Armentano, D

Smith, MP

Sookdeo, CC

Zabner, J

Perricone, MA

St George, JA

Wadsworth, SC

Gregory, RJ

机构：

[1] Genzyme Corp, Framingham, MA 01701 USA

[2] Univ Iowa, Coll Med, Howard Hughes Med Inst, Iowa City, IA 52242 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 08期

关键词：

D O I：

10.1128/JVI.73.8.7031-7034.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Analysis of transgene expression under the control of the cytomegalovirus (CMV) promoter from adenovirus vectors in which the E4 region was modified indicated that E4ORF3 is required for long-term expression in the murine lung. CMV promoter truncation led to the persistence of expression in the absence of E4, thus eliminating the ORF3 requirement.

引用

页码：7031 / 7034

页数：4

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