E4ORF3 requirement for achieving long-term transgene expression from the cytomegalovirus promoter in adenovirus vectors

被引：30

作者：

Armentano, D

Smith, MP

Sookdeo, CC

Zabner, J

Perricone, MA

St George, JA

Wadsworth, SC

Gregory, RJ

机构：

[1] Genzyme Corp, Framingham, MA 01701 USA

[2] Univ Iowa, Coll Med, Howard Hughes Med Inst, Iowa City, IA 52242 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 08期

关键词：

D O I：

10.1128/JVI.73.8.7031-7034.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Analysis of transgene expression under the control of the cytomegalovirus (CMV) promoter from adenovirus vectors in which the E4 region was modified indicated that E4ORF3 is required for long-term expression in the murine lung. CMV promoter truncation led to the persistence of expression in the absence of E4, thus eliminating the ORF3 requirement.

引用

页码：7031 / 7034

页数：4

共 50 条

[1] Transforming potential of the adenovirus type 5 E4orf3 protein
Nevels, M
Täuber, B
Kremmer, E
Spruss, T
Wolf, H
Dobner, T
JOURNAL OF VIROLOGY, 1999, 73 (02) : 1591 - 1600
[2] Regulation of adenovirus-mediated transgene expression by the viral E4 gene products:: Requirement for E4 ORF3
Lusky, M
Grave, L
Dieterlé, A
Dreyer, D
Christ, M
Ziller, C
Furstenberger, P
Kintz, J
Hadji, DA
Pavirani, A
Mehtali, M
JOURNAL OF VIROLOGY, 1999, 73 (10) : 8308 - 8319
[3] Effect of the E4 region on the persistence of transgene expression from adenovirus vectors
Armentano, D
Zabner, J
Sacks, C
Sookdeo, CC
Smith, MP
StGeorge, JA
Wadsworth, SC
Smith, AE
Gregory, RJ
JOURNAL OF VIROLOGY, 1997, 71 (03) : 2408 - 2416
[4] Adenovirus 5 E1A Interacts with E4orf3 To Regulate Viral Chromatin Organization
Soriano, Andrea Michelle
Crisostomo, Leandro
Mendez, Megan
Graves, Drayson
Frost, Jasmine Rae
Olanubi, Oladunni
Whyte, Peter F.
Hearing, Patrick
Pelka, Peter
JOURNAL OF VIROLOGY, 2019, 93 (10)
[5] Long-term transgene expression in proliferating cells mediated by episomally maintained high-capacity adenovirus vectors
Kreppel, F
Kochanek, S
JOURNAL OF VIROLOGY, 2004, 78 (01) : 9 - 22
[6] Achieving reproducible and stable transgene expression for long-term therapeutic benefit
Antoniou, M.
HUMAN GENE THERAPY, 2011, 22 (10) : A2 - A2
[7] Long-term retinal transgene expression with FIV versus adenoviral vectors
Loewen, N
Leske, D
Cameron, J
Chen, Y
Whitwam, T
Simari, R
Teo, WL
Fautsch, M
Poeschla, E
Holmes, J
MOLECULAR VISION, 2004, 10 (35): : 272 - 280
[8] Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes
Araujo, FD
Stracker, TH
Carson, CT
Lee, DV
Weitzman, MD
JOURNAL OF VIROLOGY, 2005, 79 (17) : 11382 - 11391
[9] Long-Term Transgene Expression Mediated by Adenovirus in Islet Transplantation: Characterizations and Impacts
Cheng, J.
Sung, R.
TRANSPLANTATION, 2012, 94 (10) : 700 - 701
[10] Long-term transgene expression by hepatocytes transduced with retroviral vectors requires induction of immune tolerance to the transgene
Pupi, J
Guillonneau, C
Picard, V
Cuturi, MC
Ferry, N
Anegon, I
MOLECULAR THERAPY, 2004, 9 : S124 - S125

← 1 2 3 4 5 →