Residue depletion of albendazole and its metabolites in aquacultured yellow perch (Perca flavescens)

被引：8

作者：

Yu, D. ^{[1
]}

Evans, E. R. ^{[1
]}

Hasbrouck, N. ^{[1
]}

Reimschuessel, R. ^{[1
]}

Shaikh, B. ^{[1
]}

机构：

[1] US FDA, Ctr Vet Med, Res Off, Laurel, MD 20708 USA

来源：

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS | 2012年 / 35卷 / 06期

关键词：

CHANNEL CATFISH; RAINBOW-TROUT; MUSCLE-TISSUE; BIOTRANSFORMATION; KINETICS; TILAPIA;

D O I：

10.1111/j.1365-2885.2011.01354.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Yu, D., Evans, E. R., Hasbrouck, N., Reimschuessel, R., Shaikh, B. Residue depletion of albendazole and its metabolites in aquacultured yellow perch (Perca flavescens). J. vet. Pharmacol. Therap. 35, 560562. Metabolism and residue depletion studies are conducted to determine the marker residue (MR) of a drug in a target tissue of food animals. The MR is used to monitor potential unauthorized use of drugs. The current work is a continuation of our efforts to study metabolism and depletion profiles of albendazole in multiple finfish species to determine a common MR. The results of this study suggest that albendazole sulfone metabolite could potentially serve as MR for albendazole in yellow perch muscle, similar to channel catfish and hybrid striped bass as reported previously by us.

引用

页码：560 / 562

页数：3

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