No association between serotonin transporter gene polymorphisms and personality traits

被引：0
|
作者：
Gustavsson, JP [1 ]
Nöthen, MM
Jönsson, EG
Neidt, H
Forslund, K
Rylander, G
Mattila-Evenden, M
Sedvall, GC
Propping, P
Åsberg, M
机构：
[1] Karolinska Inst, Dept Clin Neurosci, Psychol Sect, SE-17176 Stockholm, Sweden
[2] Univ Skovde, Dept Hlth Sci, Skovde, Sweden
[3] Univ Bonn, Inst Human Genet, D-5300 Bonn, Germany
来源：
AMERICAN JOURNAL OF MEDICAL GENETICS | 1999年 / 88卷 / 04期
关键词：
neuroticism; genetics; association study; serotonin transporter; promoter; polymorphism; Karolinska Scales;
D O I：
10.1002/(SICI)1096-8628(19990820)88:4<430::AID-AJMG23>3.0.CO;2-1
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Human family and twin studies have established considerable heritable components in personality traits as assessed by self-report questionnaires. Recently, an association between a functional polymorphism in the upstream regulatory region of the serotonin transporter gene and neuroticism-related personality traits was reported. Two different serotonin transporter polymorphisms including the previously associated variant were genotyped in two samples of healthy Swedish subjects (n = 127 and n = 178, respectively) assessed with the Karolinska Scales of Personality (KSP) inventory. No statistically significant association between serotonin transporter polymorphisms and any of the eight neuroticism-related KSP scales was found. Thus, the previously reported association between serotonin transporter alleles and neuroticism-related personality traits could not be replicated in the present study. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:439-436, 1999, (C) 1999 Wiley-Liss, Inc.
引用
收藏
页码：430 / 436
页数：7
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